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Protein Page:
VAMP8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VAMP8 Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Belongs to the synaptobrevin family. Note: This description may include information from UniProtKB.
Protein type: Vesicle; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p12-p11.2
Cellular Component: cytoplasm; cytosol; early endosome; late endosome membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome; secretory granule membrane; SNARE complex; vesicle
Molecular Function: chloride channel inhibitor activity; protein binding; SNAP receptor activity; SNARE binding
Biological Process: entry of virus into host cell; eosinophil degranulation; neutrophil degranulation; post-Golgi vesicle-mediated transport; vesicle fusion
Reference #:  Q9BV40 (UniProtKB)
Alt. Names/Synonyms: EDB; Endobrevin; VAMP-8; VAMP8; Vesicle-associated membrane protein 8; vesicle-associated membrane protein 8 (endobrevin)
Gene Symbols: VAMP8
Molecular weight: 11,438 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VAMP8

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S5‑p ___MEEAsEGGGNDR
0 1 G7 _MEEAsEGGGNDRVR
0 9 S18‑p DRVRNLQsEVEGVkN
0 28 K24‑ub QsEVEGVkNIMtQNV
0 2 T28‑p EGVkNIMtQNVERIL
0 37 K47‑ub NLEHLRNktEDLEAt
0 46 T48‑p LEHLRNktEDLEAts
0 24 T54‑p ktEDLEAtsEHFkTT
0 7 S55‑p tEDLEAtsEHFkTTS
0 15 K59‑ub EAtsEHFkTTSQkVA
0 1 S62 sEHFkTTSQkVARKF
0 2 K64‑ub HFkTTSQkVARKFWW
  mouse

 
S5‑p ___MEEAsGsAGNDR
S7‑p _MEEAsGsAGNDRVR
S18‑p DRVRNLQsEVEGVkN
K24‑ub QsEVEGVkNIMTQNV
T28 EGVkNIMTQNVERIL
K47‑ub NLDHLRNktEDLEAt
T48‑p LDHLRNktEDLEAts
T54‑p ktEDLEAtsEHFkTT
S55‑p tEDLEAtsEHFkTTs
K59‑ub EAtsEHFkTTsQKVA
S62‑p sEHFkTTsQKVARKF
K64 HFkTTsQKVARKFWW
  rat

 
S4 ____MEASGSAGNDR
S6 __MEASGSAGNDRVR
S17 DRVRNLQSEVEGVKN
K23 QSEVEGVKNIMTQNV
T27 EGVKNIMTQNVERIL
K46 NLDHLRNKTEDLEAt
T47 LDHLRNKTEDLEAtS
T53‑p KTEDLEAtSEHFKTT
S54 TEDLEAtSEHFKTTS
K58 EAtSEHFKTTSQKVA
S61 SEHFKTTSQKVARKF
K63 HFKTTSQKVARKFWW
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