Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
VAMP8 (human)

VAMP8 Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Belongs to the synaptobrevin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: cytoplasm; cytosol; early endosome; late endosome membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome; secretory granule membrane; SNARE complex; vesicle
Molecular Function: chloride channel inhibitor activity; protein binding; SNAP receptor activity; SNARE binding
Biological Process: autophagic vacuole docking; entry of virus into host cell; eosinophil degranulation; neutrophil degranulation; post-Golgi vesicle-mediated transport; vesicle fusion
Reference #:  Q9BV40 (UniProtKB)
Alt. Names/Synonyms: EDB; Endobrevin; VAMP-8; VAMP8; Vesicle-associated membrane protein 8; vesicle-associated membrane protein 8 (endobrevin)
Gene Symbols: VAMP8
Molecular weight: 11,438 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene