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Protein Page:
TH (rat)

Overview
TH an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; EC 1.14.16.2; Oxidoreductase; Amino Acid Metabolism - tyrosine; Vesicle; Mitochondrial
Cellular Component: axon; cell soma; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; dendrite; internal side of plasma membrane; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum; synaptic vesicle; terminal button
Molecular Function: amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; monooxygenase activity; oxygen binding; protein binding; protein domain specific binding; tyrosine 3-monooxygenase activity
Biological Process: catecholamine biosynthetic process; cerebral cortex development; circadian sleep/wake cycle; cognition; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; multicellular organismal aging; norepinephrine biosynthetic process; organ morphogenesis; phthalate metabolic process; phytoalexin metabolic process; protein homotetramerization; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone stimulus; response to drug; response to electrical stimulus; response to estradiol stimulus; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to insecticide; response to light stimulus; response to lipopolysaccharide; response to metal ion; response to nicotine; response to nutrient levels; response to organic cyclic substance; response to peptide hormone stimulus; response to pyrethroid; response to salt stress; response to steroid hormone stimulus; response to water deprivation; response to zinc ion; sensory perception of sound; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; synaptic vesicle amine transport; terpene metabolic process; visual perception
Reference #:  P04177 (UniProtKB)
Alt. Names/Synonyms: TH; The; TY3H; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols: Th
Molecular weight: 55,966 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TH

Protein Structure Not Found.
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STRING  |  Reactome  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Sites Implicated In
enzymatic activity, induced: S19‑p, S31‑p, S40‑p
molecular association, regulation: S19‑p, S40‑p
protein conformation: S19‑p, S40‑p
protein stabilization: S8‑p, S19‑p, S31‑p, S40‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 1 T3 _____MPTPSAPsPQ
5 1 S8‑p MPTPSAPsPQPKGFR
39 11 S19‑p KGFRRAVsEQDAKQA
0 1 A23 RAVsEQDAKQAEAVT
0 1 T30 AKQAEAVTsPRFIGR
36 7 S31‑p KQAEAVTsPRFIGRR
53 14 S40‑p RFIGRRQsLIEDARK
0 1 S88 AVLNLLFSLRGTKPS
1 0 S153‑p LSSVRRVsDDVRSAR
0 1 Y200 PGFSDQVYRQRRKLI
0 1 Y389 QNGELKAYGAGLLSS
1 0 S405 GELLHSLSEEPEVRA
0 4 S472‑p LAIDVLDsPHTIQRS
3370 : Phospho-Tyrosine Hydroxylase (Ser31) Antibody
13041 : Phospho-Tyrosine Hydroxylase (Ser31) (D6I9V) Rabbit mAb
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  human

► Hide Isoforms
 
T3‑p _____MPtPDATTPQ
T8 MPtPDATTPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMVRGQGAP
S62‑p SYTPTPRsPRFIGRR
S71‑p RFIGRRQsLIEDARK
S118‑p AVLNLLFsPRATKPS
S183 LSGVRQVSEDVRSPA
Y230‑p PGFSDQVyRQRRKLI
Y419‑p QNGEVKAyGAGLLSS
S435 GELLHCLSEEPEIRA
S502‑p LAIDVLDsPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso2  
T3 _____MPTPDATTPQ
T8 MPTPDATTPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMGAPGPSL
S58‑p SYTPTPRsPRFIGRR
S67‑p RFIGRRQsLIEDARK
S114 AVLNLLFSPRATKPS
S179 LSGVRQVSEDVRSPA
Y226 PGFSDQVYRQRRKLI
Y415 QNGEVKAYGAGLLSS
S431 GELLHCLSEEPEIRA
S498 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso3  
T3 _____MPTPDATTPQ
T8 MPTPDATTPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMsPRFIGR
S31‑p KQAEAIMsPRFIGRR
S40‑p RFIGRRQsLIEDARK
S87 AVLNLLFSPRATKPS
S152 LSGVRQVSEDVRSPA
Y199 PGFSDQVYRQRRKLI
Y388 QNGEVKAYGAGLLSS
S404‑p GELLHCLsEEPEIRA
S471 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  TH iso4  
T3 _____MPTPDATTPQ
T8 MPTPDATTPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMVRGQsPR
S35‑p AIMVRGQsPRFIGRR
S44‑p RFIGRRQsLIEDARK
S91 AVLNLLFSPRATKPS
S156 LSGVRQVSEDVRSPA
Y203 PGFSDQVYRQRRKLI
Y392 QNGEVKAYGAGLLSS
S408 GELLHCLSEEPEIRA
S475 LAIDVLDSPQAVRRS
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  mouse

 
T3 _____MPTPSASSPQ
S8 MPTPSASSPQPKGFR
S19‑p KGFRRAVsEQDtKQA
T23‑p RAVsEQDtKQAEAVt
T30‑p tKQAEAVtsPRFIGR
S31‑p KQAEAVtsPRFIGRR
S40‑p RFIGRRQsLIEDARK
S88 AVLNLLFSLRGTKPS
S153 LSSVRRVSDDVRSAR
Y200 PGFSDQAYRQRRKLI
Y389 QNGELKAYGAGLLSS
S405 GELLHSLSEEPEVRA
S472‑p LAIDVLDsPHTIRRS
3370 : Phospho-Tyrosine Hydroxylase (Ser31) Antibody
13041 : Phospho-Tyrosine Hydroxylase (Ser31) (D6I9V) Rabbit mAb
2791 : Phospho-Tyrosine Hydroxylase (Ser40) Antibody
  cow

 
T3 _____MPTPNAASPQ
S8 MPTPNAASPQAKGFR
S19‑p KGFRRAVsELDAKQA
A23 RAVsELDAKQAEAIM
M30 AKQAEAIMsPRFVGR
S31‑p KQAEAIMsPRFVGRR
S40‑p RFVGRRQsLIQDARK
A81 AVLTLLFALPPTRPP
A146 LSALRRVAEDVRAAG
Y193 PGFSDQAYRQRRKLI
Y382 QNGEVKAYGAGLLSS
S398 GELLHSLSEEPEIRA
S465 LAIDVLDSPHAIRHA
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