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Protein Page:
SLC1A3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC1A3 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 5p13
Cellular Component: membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity
Biological Process: glutamate secretion; ion transport; L-glutamate import; neurotransmitter uptake; positive regulation of defense response to virus by host; synaptic transmission
Disease: Episodic Ataxia, Type 6
Reference #:  P43003 (UniProtKB)
Alt. Names/Synonyms: EA6; EAA1; EAAT1; Excitatory amino acid transporter 1; FLJ25094; GLAST; GLAST-1; GLAST1; SLC1A3; Sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; Solute carrier family 1 member 3
Gene Symbols: SLC1A3
Molecular weight: 59,572 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC1A3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T2‑p ______MtKsNGEEP
0 1 K3 _____MtKsNGEEPK
0 1 S4‑p ____MtKsNGEEPKM
0 1 T26 QQGVRKRTLLAKKKV
0 1 N35 LAKKKVQNITkEDVK
0 1 K38‑ac KKVQNITkEDVKSYL
0 1 K42 NITkEDVKSYLFRNA
0 2 K79 RMSYREVKYFsFPGE
0 1 S82‑p YREVKYFsFPGELLM
0 1 K188 NLVEACFKQFKTNYE
0 1 K384 EENNGVDKRVTRFVL
0 1 K503 HLSRHELKNRDVEMG
0 20 S512‑p RDVEMGNsVIEENEM
0 2 K520‑ub VIEENEMkkPyQLIA
0 1 K521 IEENEMkKPyQLIAQ
0 2 K521‑ub IEENEMkkPyQLIAQ
0 11 Y523‑p ENEMkkPyQLIAQDN
0 1 K534 AQDNETEKPIDSETk
0 3 K534‑ub AQDNETEkPIDSETk
0 1 S538 ETEkPIDSETkM___
0 2 K541‑ub kPIDSETkM______
  mouse

 
T2 ______MTkSNGEEP
K3‑ac _____MTkSNGEEPR
S4 ____MTkSNGEEPRM
T26‑p QQGVRKRtLLAKKKV
S35‑p LAKKKVQsLTKEDVk
K38 KKVQsLTKEDVkSYL
K42‑ub sLTKEDVkSYLFRNA
K79 KMSYREVKYFSFPGE
S82 YREVKYFSFPGELLM
K188 NLVEACFKQFKTSYE
K384‑ub EENNGVDkRITRFVL
K503‑ub HLSRHELkNRDVEMG
S512‑p RDVEMGNsVIEENEM
K520‑ub VIEENEMkkPyQLIA
K521 IEENEMkKPyQLIAQ
K521‑ub IEENEMkkPyQLIAQ
Y523‑p ENEMkkPyQLIAQDN
K534 AQDNEPEKPVADsET
K534‑ub AQDNEPEkPVADsET
S539‑p PEkPVADsETkM___
K542‑ub PVADsETkM______
  rat

 
T2 ______MTKSNGEEP
K3 _____MTKSNGEEPR
S4 ____MTKSNGEEPRM
T26 QQGVRKRTLLAKKKV
N35 LAKKKVQNITKEDVK
K38 KKVQNITKEDVKSYL
K42 NITKEDVKSYLFRNA
K79‑ac KMSYREVkYFSFPGE
S82 YREVkYFSFPGELLM
K188‑ac NLVEACFkQFKTSYE
K384 EENNGVDKRITRFVL
K503 HLSRHELKNRDVEMG
S512‑p RDVEMGNsVIEENEM
K520 VIEENEMKkPyQLIA
K521‑ac IEENEMKkPyQLIAQ
K521 IEENEMKKPyQLIAQ
Y523‑p ENEMKkPyQLIAQDN
K534‑ac AQDNEPEkPVADSET
K534 AQDNEPEKPVADSET
S539 PEkPVADSETKM___
K542 PVADSETKM______
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