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Protein Page:
SLC1A3 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SLC1A3 Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 5p13
Cellular Component: basolateral plasma membrane; cell soma; cell surface; dendritic spine; fibril; integral to membrane; membrane; mitochondrial inner membrane; plasma membrane
Molecular Function: glutamate binding; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; sodium:dicarboxylate symporter activity
Biological Process: auditory behavior; cranial nerve development; gamma-aminobutyric acid biosynthetic process; glutamate biosynthetic process; glutamate secretion; ion transport; L-glutamate import; malate-aspartate shuttle; neuromuscular process controlling balance; neuron morphogenesis during differentiation; neurotransmitter secretion; neurotransmitter uptake; positive regulation of defense response to virus by host; positive regulation of synaptic transmission; response to antibiotic; response to drug; response to light stimulus; response to wounding; sensory perception of sound; synaptic transmission; transmembrane transport
Disease: Episodic Ataxia, Type 6
Reference #:  P43003 (UniProtKB)
Alt. Names/Synonyms: EA6; EAA1; EAAT1; Excitatory amino acid transporter 1; FLJ25094; GLAST; GLAST-1; GLAST1; SLC1A3; Sodium-dependent glutamate/aspartate transporter 1; solute carrier family 1 (glial high affinity glutamate transporter), member 3; Solute carrier family 1 member 3
Gene Symbols: SLC1A3
Molecular weight: 59,572 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SLC1A3

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K3 _____MTKSNGEEPK
0 1 N35 LAKKKVQNITkEDVK
0 1 K38‑ac KKVQNITkEDVKSYL
0 1 K42 NITkEDVKSYLFRNA
0 2 K79 RMSYREVKYFsFPGE
0 1 S82‑p YREVKYFsFPGELLM
0 1 K188 NLVEACFKQFKTNYE
0 1 K384 EENNGVDKRVTRFVL
0 1 K503 HLSRHELKNRDVEMG
0 19 S512‑p RDVEMGNsVIEENEM
0 2 K520‑ub VIEENEMkkPyQLIA
0 1 K521 IEENEMkKPyQLIAQ
0 2 K521‑ub IEENEMkkPyQLIAQ
0 11 Y523‑p ENEMkkPyQLIAQDN
0 1 K534 AQDNETEKPIDSETk
0 3 K534‑ub AQDNETEkPIDSETk
0 1 S538 ETEkPIDSETkM___
0 2 K541‑ub kPIDSETkM______
  mouse

 
K3‑ac _____MTkSNGEEPR
S35‑p LAKKKVQsLTKEDVk
K38 KKVQsLTKEDVkSYL
K42‑ub sLTKEDVkSYLFRNA
K79 KMSYREVKYFSFPGE
S82 YREVKYFSFPGELLM
K188 NLVEACFKQFKTSYE
K384‑ub EENNGVDkRITRFVL
K503‑ub HLSRHELkNRDVEMG
S512‑p RDVEMGNsVIEENEM
K520‑ub VIEENEMkkPyQLIA
K521 IEENEMkKPyQLIAQ
K521‑ub IEENEMkkPyQLIAQ
Y523‑p ENEMkkPyQLIAQDN
K534 AQDNEPEKPVADsET
K534‑ub AQDNEPEkPVADsET
S539‑p PEkPVADsETkM___
K542‑ub PVADsETkM______
  rat

 
K3 _____MTKSNGEEPR
N35 LAKKKVQNITKEDVK
K38 KKVQNITKEDVKSYL
K42 NITKEDVKSYLFRNA
K79‑ac KMSYREVkYFSFPGE
S82 YREVkYFSFPGELLM
K188‑ac NLVEACFkQFKTSYE
K384 EENNGVDKRITRFVL
K503 HLSRHELKNRDVEMG
S512‑p RDVEMGNsVIEENEM
K520 VIEENEMKkPyQLIA
K521‑ac IEENEMKkPyQLIAQ
K521 IEENEMKKPyQLIAQ
Y523‑p ENEMKkPyQLIAQDN
K534‑ac AQDNEPEkPVADSET
K534 AQDNEPEKPVADSET
S539 PEkPVADSETKM___
K542 PVADSETKM______
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