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Protein Page:
IL-28B (human)

Overview
IL-28B Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: extracellular region; extracellular space; intracellular
Molecular Function: cytokine activity; receptor binding
Biological Process: defense response to virus; innate immune response; JAK-STAT cascade; negative regulation of viral genome replication; positive regulation of immune response; regulation of T cell activation
Disease: Hepatitis C Virus, Susceptibility To
Reference #:  Q8IZI9 (UniProtKB)
Gene Symbols: IFNL3
Molecular weight: 21,706 Da
Basal Isoelectric point: 8.69  Predict pI for various phosphorylation states
Select Structure to View Below

IL-28B

Protein Structure Not Found.
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