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Protein Page:
PSME3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PSME3 a protein implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Homohexamer. Significantly elevated in colorectal cancer patients compared with healthy donors and patients with benign bowel disease. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protease; Nuclear receptor co-regulator; Proteasome complex
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus; proteasome activator complex; proteasome complex
Molecular Function: identical protein binding; p53 binding; protein binding
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptosis; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Reference #:  P61289 (UniProtKB)
Alt. Names/Synonyms: 11S regulator complex gamma subunit; 11S regulator complex subunit gamma; Activator of multicatalytic protease subunit 3; Ki; Ki antigen; Ki nuclear autoantigen; Ki); PA28-gamma; PA28g; PA28gamma; proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Proteasome activator 28 subunit gamma; proteasome activator 28-gamma; Proteasome activator complex subunit 3; PSME3; REG-gamma
Gene Symbols: PSME3
Molecular weight: 29,506 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PSME3

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S247‑p
molecular association, regulation: S247‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 1 K6‑ac __MASLLkVDQEVkL
0 1 K6‑ub __MASLLkVDQEVkL
1 0 K6‑sm __MASLLkVDQEVkL
0 1 K6‑sc __MASLLkVDQEVkL
1 0 K12‑sm LkVDQEVkLkVDsFR
1 0 K14‑ac VDQEVkLkVDsFRER
0 30 K14‑ub VDQEVkLkVDsFRER
1 0 K14‑sm VDQEVkLkVDsFRER
0 3 S17‑p EVkLkVDsFRERIts
0 42 T23‑p DsFRERItsEAEDLV
0 119 S24‑p sFRERItsEAEDLVA
0 3 K36‑ub LVANFFPkkLLELDS
0 4 K37‑ub VANFFPkkLLELDSF
0 1 S75‑p DPILLTNsHDGLDGP
0 1 Y84‑p DGLDGPTyKKRRLDE
0 1 K86 LDGPTyKKRRLDECE
0 1 K100‑ub EEAFQGTkVFVMPNG
0 1 K110‑ub VMPNGMLksNQQLVD
0 1 S111‑p MPNGMLksNQQLVDI
0 1 K121‑m1 QLVDIIEkVKPEIRL
0 5 K121‑ub QLVDIIEkVKPEIRL
0 3 K132‑ub EIRLLIEkCNTVKMW
0 1 T167‑p ETVAELRtVEsEAAs
0 1 S170‑p AELRtVEsEAAsyLD
0 1 S174‑p tVEsEAAsyLDQIsR
0 1 Y175‑p VEsEAAsyLDQIsRY
0 1 S180‑p AsyLDQIsRYYITRA
1 1 K195‑ac KLVSKIAkYPHVEDY
0 1 K195‑ub KLVSKIAkYPHVEDY
0 2 T205 HVEDYRRTVTEIDEk
0 2 T207 EDYRRTVTEIDEkEy
0 1 K212‑m1 TVTEIDEkEyISLRL
0 1 Y214‑p TEIDEkEyISLRLII
1 1 S247‑p EKIKRPRssNAETLy
0 1 S248‑p KIKRPRssNAETLy_
0 1 Y254‑p ssNAETLy_______
  mouse

 
K6 __MASLLKVDQEVKL
K6 __MASLLKVDQEVKL
K6 __MASLLKVDQEVKL
K6 __MASLLKVDQEVKL
K12 LKVDQEVKLkVDsFR
K14 VDQEVKLKVDsFRER
K14‑ub VDQEVKLkVDsFRER
K14 VDQEVKLKVDsFRER
S17‑p EVKLkVDsFRERIts
T23‑p DsFRERItsEAEDLV
S24‑p sFRERItsEAEDLVA
K36‑ub LVANFFPkkLLELDS
K37‑ub VANFFPkkLLELDSF
S75 DPILLTNSHDGLDGP
Y84 DGLDGPTYKkRRLDE
K86‑ub LDGPTYKkRRLDECE
K100 EEAFQGTKVFVMPNG
K110 VMPNGMLKSNQQLVD
S111 MPNGMLKSNQQLVDI
K121 QLVDIIEKVKPEIRL
K121‑ub QLVDIIEkVKPEIRL
K132 EIRLLIEKCNTVKMW
T167 ETVAELRTVESEAAS
S170 AELRTVESEAASYLD
S174 TVESEAASYLDQISR
Y175 VESEAASYLDQISRY
S180 ASYLDQISRYYITRA
K195 KLVSKIAKYPHVEDY
K195 KLVSKIAKYPHVEDY
T205‑p HVEDYRRtVtEIDEK
T207‑p EDYRRtVtEIDEKEY
K212 tVtEIDEKEYISLRL
Y214 tEIDEKEYISLRLII
S247 EKIKRPRSSNAETLY
S248 KIKRPRSSNAETLY_
Y254 SSNAETLY_______
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