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Protein Page:
IL2 (human)

Overview
IL2 Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Cytokine; Oncoprotein; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q26-q27
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; growth factor activity; interleukin-2 receptor binding; kinase activator activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: cell adhesion; cell-cell signaling; immune response; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; negative regulation of B cell apoptosis; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; T cell differentiation
Reference #:  P60568 (UniProtKB)
Alt. Names/Synonyms: aldesleukin; IL-2; IL2; interleukin 2; Interleukin-2; involved in regulation of T-cell clonal expansion; lymphokine; T cell growth factor; T-cell growth factor; TCGF
Gene Symbols: IL2
Molecular weight: 17,628 Da
Basal Isoelectric point: 7.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IL2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S8‑p MYRMQLLsCIALSLA
0 3 Y65‑p RMLTFKFyMPKKATE
  mouse

 
S8 MYSMQLASCVTLTLV
Y79 RMLTFKFYLPKQATE
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