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Protein Page:
CYR61 (human)

Overview
CYR61 Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: extracellular matrix binding; heparin binding; insulin-like growth factor binding; integrin binding
Biological Process: anatomical structure morphogenesis; cell adhesion; cell proliferation; cell-cell signaling; chemotaxis; extracellular matrix organization and biogenesis; intussusceptive angiogenesis; negative regulation of apoptosis; osteoblast differentiation; positive regulation of BMP signaling pathway; positive regulation of caspase activity; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of osteoblast proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; regulation of cell growth; signal transduction
Reference #:  O00622 (UniProtKB)
Alt. Names/Synonyms: CCN family member 1; CCN1; CYR61; Cysteine-rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61; cysteine-rich, angiogenic inducer, 61; cysteine-rich, anigogenic inducer, 61; GIG1; IBP-10; IGF-binding protein 10; IGFBP-10; IGFBP10; Insulin-like growth factor-binding protein 10; Protein CYR61; Protein GIG1
Gene Symbols: CYR61
Molecular weight: 42,027 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CYR61

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T14‑p RALALVVtLLHLTRL
0 1 S84‑p ECNFGASstALKGIC
0 1 T85‑p CNFGASstALKGICR
0 1 S167‑p EWVCDEDsIKDPMED
0 1 S188‑p KELGFDAsEVELTRN
0 1 Y221‑p GMEPRILyNPLQGQK
0 3 Y277‑p RPCGQPVysSLKKGK
0 1 S278‑p PCGQPVysSLKKGKK
0 1 S344 CEDGETFSKNVMMIQ
  mouse

 
T14 RTLAVAVTLLHLTRL
S84 ECNFGASSTALKGIC
T85 CNFGASSTALKGICR
S167 EWVCDEDSIKDSLDD
S184 DLLGLDASEVELTRN
F217 GTEPRVLFNPLHAHG
Y275 RPCGQPVYSSLKKGK
S276 PCGQPVYSSLKKGKK
S342‑p CEDGEMFsKNVMMIQ
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