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Protein Page:
DLL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DLL1 Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell development/differentiation
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: adherens junction; apical plasma membrane; cytoplasmic vesicle; extracellular region; integral to plasma membrane; lipid raft; plasma membrane
Molecular Function: calcium ion binding; Notch binding; protein binding; Tat protein binding
Biological Process: astrocyte development; cell differentiation; cell fate determination; cerebellar molecular layer formation; cerebellar Purkinje cell layer structural organization; compartment specification; determination of left/right symmetry; heart looping; hemopoiesis; inner ear development; lateral inhibition; marginal zone B cell differentiation; negative regulation of auditory receptor cell differentiation; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of epidermal cell differentiation; negative regulation of epithelial cell differentiation; negative regulation of interleukin-10 production; negative regulation of myeloid cell differentiation; negative regulation of myoblast differentiation; negative regulation of neuron differentiation; neuron fate specification; Notch receptor processing; Notch signaling pathway; organ growth; positive regulation of cell proliferation; positive regulation of endocytosis; positive regulation of Notch signaling pathway; positive regulation of skeletal muscle growth; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; regulation of blood pressure; regulation of cell adhesion; regulation of cell division; regulation of growth; regulation of neurogenesis; regulation of skeletal muscle growth; regulation of somitogenesis; retina development in camera-type eye; retina morphogenesis in camera-type eye; skeletal muscle growth; somite specification; somitogenesis; spinal cord development
Reference #:  O00548 (UniProtKB)
Gene Symbols: DLL1
Molecular weight: 78,056 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DLL1

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K35‑ac KLQEFVNkKGLLGNR
0 1 R57 GPPPCACRTFFRVCL
0 1 S603‑p CQREKDIsVSIIGAT
1 1 A638 GFKARYPAVDyNLVQ
0 3 Y641‑p ARYPAVDyNLVQDLK
1 1 S694 SERKRPDSGCSTSKD
1 1 S697 KRPDSGCSTSKDtKy
0 1 T702‑p GCSTSKDtKyQsVYV
0 1 Y704‑p STSKDtKyQsVYVIS
0 1 S706‑p SKDtKyQsVYVISEE
  mouse

 
K35 KLQEFVNKKGLLGNR
R56‑m1 SGPPCACrTFFRVCL
S603 CQREKDVSVSIIGAT
T638‑p SFKVRYPtVDYNLVR
Y641 VRYPtVDYNLVRDLK
S693‑p PDRKRPEsVYsTSKD
S696‑p KRPEsVYsTSKDTKY
T701 VYsTSKDTKYQSVYV
Y703 sTSKDTKYQSVYVLS
S705 SKDTKYQSVYVLSAE
  rat

 
K35 KLQEFVNKKGLLGNR
R56 SGPPCACRTFFRVCL
S595 CQREKDVSVSIIGAT
T630 SFKARYPTVDYNLIR
Y633 ARYPTVDYNLIRDLK
S685 PDRKRPESVYSTSKD
S688 KRPESVYSTSKDTKY
T693 VYSTSKDTKYQSVYV
Y695 STSKDTKYQSVYVLS
S697 SKDTKYQSVYVLSAE
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