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Protein Page:
CTSB (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CTSB Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. Belongs to the peptidase C1 family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Autophagy; EC 3.4.22.1; Protease
Chromosomal Location of Human Ortholog: 8p22
Cellular Component: apical plasma membrane; caveola; external side of plasma membrane; extracellular region; extracellular space; intracellular; intracellular membrane-bound organelle; lysosome; melanosome; mitochondrion; nucleolus; perinuclear region of cytoplasm; sarcolemma
Molecular Function: collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; kininogen binding; peptidase activity; peptide binding; protein binding; protein self-association; proteoglycan binding
Biological Process: autophagy; collagen catabolic process; decidualization; entry of virus into host cell; epithelial cell differentiation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; innate immune response; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of apoptosis; regulation of catalytic activity; response to amine stimulus; response to ethanol; response to glucose stimulus; response to organic cyclic substance; response to peptide hormone stimulus; response to wounding; skeletal muscle development; spermatogenesis; toll-like receptor signaling pathway
Reference #:  P07858 (UniProtKB)
Alt. Names/Synonyms: amyloid precursor protein secretase; APP secretase; APPS; CATB; Cathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; Cathepsin B1; CPSB; CTSB; cysteine protease
Gene Symbols: CTSB
Molecular weight: 37,822 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CTSB

Protein Structure Not Found.


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Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y33‑p LSDELVNyVNKRNTT
0 1 D77‑ca QRVMFTEdLKLPASF
0 1 S107 RDQGSCGSCWAFGAV
0 1 S169‑p WTRKGLVsGGLyESH
0 1 Y173‑p GLVsGGLyESHVGCR
0 2 Y215‑p SKICEPGySPTyKQD
0 2 Y219‑p EPGySPTyKQDkHYG
0 1 K220 PGySPTyKQDkHYGY
0 1 K223‑ub SPTyKQDkHYGYNSY
0 1 K237‑ub YSVSNSEkDIMAEIY
0 1 K311 WGDNGFFKILRGQDH
  mouse

 
Y33 LSDDLINYINKQNTT
D77 GRVAFGEDIDLPETF
S107‑p RDQGSCGsCWAFGAV
S169 WTKKGLVSGGVYNSH
Y173 GLVSGGVYNSHVGCL
Y215 NKSCEAGYSPSYkED
Y219 EAGYSPSYkEDKHFG
K220‑ub AGYSPSYkEDKHFGY
K223 SPSYkEDKHFGYTSY
K237 YSVSNSVKEIMAEIY
K311‑ac WGDNGFFkILRGENH
  rat

 
Y33 LSDDMINYINKQNTT
D77 ERVGFSEDINLPESF
S107 RDQGSCGSCWAFGAV
S169 WTRKGLVSGGVYNSH
Y173 GLVSGGVYNSHIGCL
Y215 NKMCEAGYSTSYKED
Y219 EAGYSTSYKEDKHYG
K220 AGYSTSYKEDKHYGY
K223 STSYKEDKHYGYTSY
K237 YSVSDSEKEIMAEIY
K311 WGDNGFFKILRGENH
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