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Protein Page:
IFITM1 (human)

Overview
IFITM1 IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. Belongs to the CD225/Dispanin family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: membrane; plasma membrane
Molecular Function: protein binding; receptor signaling protein activity
Biological Process: cell surface receptor linked signal transduction; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; positive regulation of osteoblast differentiation; regulation of immune response; response to virus
Reference #:  P13164 (UniProtKB)
Alt. Names/Synonyms: 9-27; CD225; IFI17; IFITM1; IFM1; interferon-induced protein 17; interferon-induced transmembrane protein 1; Leu-13 antigen; LEU13; nterferon-inducible protein 9-27
Gene Symbols: IFITM1
Molecular weight: 13,964 Da
Basal Isoelectric point: 7.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IFITM1

Protein Structure Not Found.


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