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Protein Page:
IL17F (human)

Overview
IL17F Stimulates the production of other cytokines such as IL- 6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis. Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6). CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. Belongs to the IL-17 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: extracellular region; extracellular space
Molecular Function: cytokine activity; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; protein binding; protein homodimerization activity
Biological Process: cartilage development; cell surface receptor linked signal transduction; cytokine biosynthetic process; inflammatory response; lymphotoxin A biosynthetic process; negative regulation of angiogenesis; positive regulation of transcription from RNA polymerase II promoter; regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; regulation of interleukin-8 biosynthetic process; regulation of transforming growth factor beta receptor signaling pathway
Disease: Candidiasis, Familial, 6
Reference #:  Q96PD4 (UniProtKB)
Alt. Names/Synonyms: cytokine ML-1; IL-17F; IL-24; IL17F; IL24; interleukin 17F; Interleukin-17F; Interleukin-24; ML-1; ML1
Gene Symbols: IL17F
Molecular weight: 18,045 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Select Structure to View Below

IL17F

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S95 WDPNRYPSEVVQAQC
0 1 S117‑p AQGKEDIsMNSVPIQ
  mouse

 
S93 RDPHRFPSEIAEAQC
T115 AQGQEDSTMNSVAIQ
  rat

 
S93‑p RDPDRFPsEIAEAQC
S115 AQGQEDGSMNSVPIQ
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