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Protein Page:
BTC (human)

Overview
BTC Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase; Cell cycle regulation
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular region; extracellular space; integral to membrane; intracellular; plasma membrane
Molecular Function: epidermal growth factor receptor binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of apoptosis; peptidyl-tyrosine phosphorylation; phosphoinositide phosphorylation; phosphoinositide-mediated signaling; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; positive regulation of GTPase activity; positive regulation of mitosis; regulation of phosphoinositide 3-kinase cascade
Reference #:  P35070 (UniProtKB)
Gene Symbols: BTC
Molecular weight: 19,746 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
Select Structure to View Below

BTC

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y99 SCVCDEGYIGARCER
  mouse

 
Y99‑p SCICEKGyFGARCER
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