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Protein Page:
LEFTY1 (human)

Overview
LEFTY1 Required for left-right axis determination as a regulator of LEFTY2 and NODAL. Belongs to the TGF-beta family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 1q42.1
Cellular Component: extracellular space
Molecular Function: cytokine activity; growth factor activity; transforming growth factor beta receptor binding
Biological Process: cell development; cell growth; determination of left/right symmetry; heart morphogenesis; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway
Reference #:  O75610 (UniProtKB)
Alt. Names/Synonyms: BMP-17; BMP17; lefty b; lefty-1; lefty-b; lefty1; leftyb; stra3
Gene Symbols: LEFTY1
Molecular weight: 40,880 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LEFTY1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S79‑p RSRGKRFsQsFREVA
0 1 S81‑p RGKRFsQsFREVAGR
  mouse

 
S79 RSRGKRFSQNLREVA
N81 RGKRFSQNLREVAGR
  rat

 
S79 RSRGKRFSQNFREVA
N81 RGKRFSQNFREVAGR
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