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Protein Page:
LTA (human)

LTA Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS). PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). Belongs to the tumor necrosis factor family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Cytokine; Secreted, signal peptide; Apoptosis
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: extracellular space; plasma membrane
Molecular Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding
Biological Process: apoptosis; cell-cell signaling; defense response to Gram-positive bacterium; humoral immune response; lymph node development; negative regulation of fibroblast proliferation; positive regulation of apoptosis; positive regulation of chronic inflammatory response to antigenic stimulus; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of interferon-gamma production; response to drug; response to hypoxia; response to lipopolysaccharide; response to nutrient; signal transduction; tumor necrosis factor-mediated signaling pathway
Disease: Leprosy, Susceptibility To, 4; Myocardial Infarction, Susceptibility To; Psoriatic Arthritis, Susceptibility To
Reference #:  P01374 (UniProtKB)
Alt. Names/Synonyms: LT-alpha; lymphotoxin-alpha; TNF-beta; TNFB; TNFSF1; tumor necrosis factor ligand superfamily member 1
Gene Symbols: LTA
Molecular weight: 22,297 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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