carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Immunoglobulin superfamily; Cell adhesion; Motility/polarity/chemotaxis
Cellular Component: adherens junction; apical plasma membrane; basal plasma membrane; cell junction; integral to membrane; integral to plasma membrane; intercellular junction; lateral plasma membrane; membrane; plasma membrane; T cell receptor complex
Molecular Function: bile acid transmembrane transporter activity; filamin binding; kinase binding; protein binding; protein dimerization activity; protein homodimerization activity; protein phosphatase binding
Biological Process: angiogenesis; bile acid and bile salt transport; cell adhesion; cell migration; homophilic cell adhesion; integrin-mediated signaling pathway; leukocyte migration; negative regulation of cytotoxic T cell degranulation; negative regulation of T cell mediated cytotoxicity; negative regulation of T cell receptor signaling pathway; regulation of cell migration
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.