Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Protein Page:
MEK2 (mouse)

Overview
MEK2 a dual-specificity protein kinase of the STE7 kinase family. Phosphorylated and activated by Raf and Mos kinases. Phosphorylates a Thr and a Tyr residue in a Thr-Glu-Tyr sequence located in the activation loop of ERK2 and ERK3. A component of MAP kinase signal transduction pathways involved in mitogen growth factor signal transduction. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Cellular Component: cell cortex; cytoplasm; cytosol; early endosome; endoplasmic reticulum; focal adhesion; Golgi apparatus; intercellular junction; internal side of plasma membrane; late endosome; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm; peroxisomal membrane
Molecular Function: ATP binding; MAP kinase kinase activity; PDZ domain binding; protein binding; protein complex scaffold; protein serine/threonine kinase activator activity; protein serine/threonine/tyrosine kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: activation of MAPK activity; heart development; MAPKKK cascade; positive regulation of axonogenesis; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of axon regeneration; regulation of protein amino acid phosphorylation; regulation of stress-activated MAPK cascade; thymus development; thyroid gland development
Reference #:  Q63932 (UniProtKB)
Alt. Names/Synonyms: AA589381; Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; MAP kinase kinase 2; MAP kinase/Erk kinase; Map2k2; MAPK/ERK kinase 2; MAPKK 2; MEK 2; Mek2; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2; MK2; Mkk2; MP2K2; OTTMUSP00000018442; Prkmk2; protein kinase, mitogen activated, kinase 2, p45
Gene Symbols: Map2k2
Molecular weight: 44,402 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEK2

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


STRING  |  Reactome  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene