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Protein Page:
TNFL9 (human)

Overview
TNFL9 Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytokine; Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extracellular space; integral to membrane; plasma membrane
Molecular Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding
Biological Process: apoptosis; cell proliferation; cell-cell signaling; immune response; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; signal transduction
Reference #:  P41273 (UniProtKB)
Gene Symbols: TNFSF9
Molecular weight: 26,625 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Select Structure to View Below

TNFL9

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y3 _____MEYASDASLD
0 1 S111 DGPLSWYSDPGLAGV
0 1 S158‑p RVVAGEGsGSVSLAL
0 1 S172‑p LHLQPLRsAAGAAAL
0 1 T182‑p GAAALALtVDLPPAS
0 1 S190‑p VDLPPASsEARNSAF
  mouse

 
Y58‑p ALPTDAAyPAVNVRD
S168‑p NTTLNWHsQDGAGSS
H215 PTFTNTGHKVQGWVS
- gap
T240 DFDNLALTVELFPCS
M248 VELFPCSMENKLVDR
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