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Protein Page:
MOB1A (human)

MOB1A Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Belongs to the MOB1/phocein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: cytosol
Molecular Function: protein binding
Reference #:  Q9H8S9 (UniProtKB)
Alt. Names/Synonyms: C2orf6; FLJ10788; FLJ11595; MATS1; MOB1; Mob1 alpha; Mob1 homolog 1B; MOB1, Mps One Binder kinase activator-like 1B (yeast); Mob1A; MOB4B; MOBK1B; MOBKL1B; MOL1B; Mps one binder kinase activator-like 1B; Protein Mob4B
Gene Symbols: MOB1A
Molecular weight: 25,080 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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