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Protein Page:
TIMP2 (human)

Overview
TIMP2 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Inhibitor; Cell development/differentiation; Extracellular matrix; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: basement membrane; cell soma; cell surface; extracellular region; extracellular space; growth cone; proteinaceous extracellular matrix
Molecular Function: enzyme activator activity; integrin binding; metal ion binding; metalloendopeptidase inhibitor activity; protease binding; protein binding
Biological Process: aging; central nervous system development; extracellular matrix disassembly; extracellular matrix organization and biogenesis; negative regulation of cell proliferation; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; negative regulation of mitotic cell cycle; negative regulation of Ras protein signal transduction; positive regulation of adenylate cyclase activity; positive regulation of MAPKKK cascade; positive regulation of neuron differentiation; regulation of Rap protein signal transduction; response to cytokine stimulus; response to drug; response to hormone stimulus
Reference #:  P16035 (UniProtKB)
Alt. Names/Synonyms: CSC-21K; metalloproteinase inhibitor 2; TIMP2; tissue inhibitor of metalloproteinase 2
Gene Symbols: TIMP2
Molecular weight: 24,399 Da
Basal Isoelectric point: 7.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TIMP2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S57‑p VSEKEVDsGNDIyGN
0 1 Y62‑p VDsGNDIyGNPIKRI
  mouse

 
S57 VSEKEVDSGNDIyGN
Y62 VDSGNDIYGNPIKRI
  rat

 
S57 VSEKEVDSGNDIYGN
Y62 VDSGNDIYGNPIKRI
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