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Protein Page:
ZNF259 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ZNF259 May be a signaling molecule that communicates mitogenic signals from the cytoplasm to the nucleus. Binds to the EGF and PDGF receptors. Binds to the elongation factor 1-alpha EF1A. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Belongs to the ZPR1 family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Nucleolus
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: axon; Cajal body; cell soma; cytoplasm; growth cone; nucleolus; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; SMN complex
Molecular Function: protein binding; receptor tyrosine kinase binding; translation initiation factor binding; zinc ion binding
Biological Process: Cajal body organization and biogenesis; cell proliferation; DNA endoreduplication; inner cell mass cell proliferation; microtubule cytoskeleton organization and biogenesis; mRNA processing; positive regulation of growth; positive regulation of protein import into nucleus; positive regulation of RNA splicing; regulation of myelination; RNA splicing; signal transduction; spinal cord development; trophectodermal cell proliferation
Reference #:  O75312 (UniProtKB)
Alt. Names/Synonyms: MGC110983; Zinc finger protein 259; Zinc finger protein ZPR1; ZNF259; ZPR1
Gene Symbols: ZPR1
Molecular weight: 50,925 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ZNF259

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S19‑p PGAAVAPsPAPAPPP
0 1 S49‑p QQPTEIEsLCMNCYC
0 1 T65‑p GMTRLLLtkIPFFRE
0 2 K66‑ub MTRLLLtkIPFFREI
0 2 K119‑ub DMNREVVkTDSAATR
0 2 K140‑ub EIPAFSQkGALTTVE
0 2 S190‑p KELKQVAsPFTLIID
0 94 K299‑ub GHRTNEVkSGGAVEP
0 1 S376‑p PFTLGDSsNPGQTER
0 28 Y451‑p NDMKTEGyEAGLAPQ
  mouse

 
S19 PGAAVGPSPAAAASP
S49 QQPTEIESLCMNCYR
T65 GTTRLLLTKIPFFRE
K66 TTRLLLTKIPFFREI
K119 DMNREVVKTDSATTR
K140 EIPAFSQKGALTTVE
S190 KDLKQMASPFTLVID
K299‑ub GHRTNEVkSGGAVEP
S376 PFTLGDSSNPDQSEK
Y451 NDMKTEGYEAGLAPQ
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