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Protein Page:
OSM (human)

Overview
OSM Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Belongs to the LIF/OSM family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: extracellular region
Molecular Function: cytokine activity; growth factor activity; oncostatin-M receptor binding
Biological Process: cell proliferation; multicellular organismal development; negative regulation of cell proliferation; negative regulation of hormone secretion; positive regulation of acute inflammatory response; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein
Reference #:  P13725 (UniProtKB)
Alt. Names/Synonyms: MGC20461; ONCM; oncostatin M; Oncostatin-M; OSM
Gene Symbols: OSM
Molecular weight: 28,484 Da
Basal Isoelectric point: 10.71  Predict pI for various phosphorylation states
Select Structure to View Below

OSM

Protein Structure Not Found.
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