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Protein Page:
Epigen (human)

Overview
Epigen Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular space; integral to plasma membrane; intracellular
Molecular Function: epidermal growth factor receptor binding; growth factor activity
Biological Process: activation of MAPK activity; angiogenesis; MAPKKK cascade; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor activity; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of mitosis
Reference #:  Q6UW88 (UniProtKB)
Alt. Names/Synonyms: EPG; EPGN; epigen; epithelial mitogen homolog
Gene Symbols: EPGN
Molecular weight: 17,091 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

Epigen

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y144 CLKLKSPYNVCSGER
  mouse

 
Y143‑p CINLKSPyIICSGGS
  rat

 
Y173 CLNVKSPYIICSGGR
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