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Protein Page:
ERP44 (human)

ERP44 Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Isomerase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q31.1
Cellular Component: cell surface; endoplasmic reticulum lumen; endoplasmic reticulum membrane; ER-Golgi intermediate compartment
Molecular Function: protein binding; protein disulfide isomerase activity
Biological Process: cell redox homeostasis; glycoprotein metabolic process; protein folding; response to unfolded protein
Reference #:  Q9BS26 (UniProtKB)
Alt. Names/Synonyms: endoplasmic reticulum resident protein 44 kDa; ER protein 44; ERP44; KIAA0573; PDIA10; protein disulfide isomerase family A, member 10; thioredoxin domain containing 4 (endoplasmic reticulum); thioredoxin domain-containing protein 4; TXNDC4
Gene Symbols: ERP44
Molecular weight: 46,971 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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