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Protein Page:
SH3GLB1 (human)

Overview
SH3GLB1 May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Binds DNM1, HTT, AMPH, BIN1 and ARFGAP1. Homodimer, and heterodimer with SH3GLB2. Binds BAX. Induction of apoptosis augments BAX binding. Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes. Belongs to the endophilin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 1p22
Cellular Component: cell-cell adherens junction; cytoplasm; midbody
Molecular Function: identical protein binding; protein binding; protein homodimerization activity
Biological Process: autophagic cell death; cellular response to amino acid starvation; cellular response to glucose starvation; positive regulation of autophagy; positive regulation of protein oligomerization; protein oligomerization; receptor catabolic process; regulation of cytokinesis; regulation of macroautophagy; regulation of protein stability
Reference #:  Q9Y371 (UniProtKB)
Alt. Names/Synonyms: Bax-interacting factor 1; Bif-1; CGI-61; dJ612B15.2; endophilin B1; Endophilin-B1; KIAA0491; SH3 domain-containing GRB2-like protein B1; SH3-containing protein SH3GLB1; SH3-domain GRB2-like endophilin B1; SH3GLB1; SHLB1
Gene Symbols: SH3GLB1
Molecular weight: 40,796 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SH3GLB1

Protein Structure Not Found.
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