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Protein Page:
G-CSF (human)

Overview
G-CSF Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Secreted, signal peptide; Cytokine; Secreted
Chromosomal Location of Human Ortholog: 17q11.2-q12
Cellular Component: extracellular space
Molecular Function: cytokine activity; enzyme binding; granulocyte colony-stimulating factor receptor binding; growth factor activity
Biological Process: cytokine and chemokine mediated signaling pathway; granulocyte differentiation; immune response; multicellular organismal development; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of myeloid cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein binding; positive regulation of protein kinase B signaling cascade; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter
Reference #:  P09919 (UniProtKB)
Alt. Names/Synonyms: C17orf33; colony stimulating factor 3 (granulocyte); CSF3; Filgrastim; G-CSF; GCSF; Granulocyte colony-stimulating factor; Lenograstim; Pluripoietin
Gene Symbols: CSF3
Molecular weight: 22,293 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Select Structure to View Below

G-CSF

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 T6‑p __MAGPAtQSPMKLM
  mouse

 
A6 __MAQLSAQRRMKLM
  rat

 
- gap
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