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Protein Page:
LAMTOR3 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
LAMTOR3 Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Interacts with MAP2K1/MEK1 and MAPK2. Interacts with MORG1. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR1; the interaction is direct. Belongs to the LAMTOR3 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q23
Cellular Component: endosome membrane; focal adhesion; lysosomal membrane
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; protein complex scaffold
Biological Process: activation of MAPKK activity; axon guidance; cell cycle arrest; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; gene expression; innate immune response; insulin receptor signaling pathway; macroautophagy; MAPKKK cascade; nerve growth factor receptor signaling pathway; positive regulation of GTPase activity; positive regulation of TOR signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; transcription initiation from RNA polymerase II promoter; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q9UHA4 (UniProtKB)
Alt. Names/Synonyms: MAP2K1IP1; MAPK scaffold protein 1; MAPKSP1; MEK-binding partner 1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1; MPKS1; PRO2783
Gene Symbols: LAMTOR3
Molecular weight: 13,623 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

LAMTOR3

Protein Structure Not Found.


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Modification Sites and Domains  
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Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K11 DLKRFLYKKLPSVEG
0 2 K62‑ub LATDQGSkLGLSKNK
  mouse

 
K11 DLKRFLYKKLPSVEG
K62‑ub LATDQGSkLGLSKNK
  rat

 
K11‑ac DLKRFLYkKLPSVEG
K62 LATDQGSKLGLSKNK
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