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Protein Page:
FasL (human)

Overview
FasL Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 1q23
Cellular Component: caveola; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; lysosomal lumen; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cytokine activity; death receptor binding; protein binding; receptor binding; tumor necrosis factor receptor binding
Biological Process: apoptosis; caspase activation; cell-cell signaling; cellular chloride ion homeostasis; endosomal lumen acidification; immune response; induction of apoptosis via death domain receptors; inflammatory cell apoptosis; negative regulation of angiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of neuron apoptosis; response to lipopolysaccharide; retinal cell programmed cell death; signal transduction; transcription, DNA-dependent
Disease: Autoimmune Lymphoproliferative Syndrome; Lung Cancer
Reference #:  P48023 (UniProtKB)
Alt. Names/Synonyms: Apoptosis antigen ligand; APT1LG1; APTL; CD95 ligand; CD95-L; CD95L; Fas antigen ligand; Fas ligand; FASL; FASLG; TNFSF6; Tumor necrosis factor ligand superfamily member 6
Gene Symbols: FASLG
Molecular weight: 31,485 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FasL

Protein Structure Not Found.
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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S231‑p MMEGKMMsYCtTGQM
0 1 T234‑p GKMMsYCtTGQMWAR
  mouse

 
N229 LMEEKRLNYCTTGQI
T232 EKRLNYCTTGQIWAH
  rat

 
N228 LMEEKKLNYCTTGQI
T231 EKKLNYCTTGQIWAH
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