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Protein Page:
FasL (human)

FasL Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects. Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q23
Cellular Component: extracellular region; extracellular space; integral to plasma membrane; nucleus; plasma membrane
Molecular Function: protein binding; receptor binding
Biological Process: apoptosis; caspase activation; cell-cell signaling; induction of apoptosis via death domain receptors; negative regulation of angiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction
Disease: Autoimmune Lymphoproliferative Syndrome; Lung Cancer
Reference #:  P48023 (UniProtKB)
Alt. Names/Synonyms: Apoptosis antigen ligand; APT1LG1; APTL; CD95 ligand; CD95-L; CD95L; Fas antigen ligand; Fas ligand; FASL; FASLG; TNFSF6; Tumor necrosis factor ligand superfamily member 6
Gene Symbols: FASLG
Molecular weight: 31,485 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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