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Protein Page:
DNMT3L (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
DNMT3L Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3. Belongs to the C5-methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Amino Acid Metabolism - cysteine and methionine
Cellular Component: condensed nuclear chromosome; cytoplasm; cytosol; nuclear heterochromatin; nucleus
Molecular Function: enzyme activator activity; enzyme binding; enzyme regulator activity; metal ion binding; protein binding
Biological Process: DNA methylation; in utero embryonic development; methylation; negative regulation of transcription, DNA-dependent; placenta development; positive regulation of catalytic activity
Reference #:  Q9CWR8 (UniProtKB)
Alt. Names/Synonyms: D6Ertd14e; DNA (cytosine-5)-methyltransferase 3-like; DNA (cytosine-5-)-methyltransferase 3-like; DNM3L; Dnmt3l; ecat7; MGC102308
Gene Symbols: Dnmt3l
Molecular weight: 47,993 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DNMT3L

Protein Structure Not Found.


STRING  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K12‑ub ETPSSCSkTLETLDL
0 2 K45‑ub LKSSPALkEDSVDVV
0 1 S61‑p EDCKEPLsPSSPPTG
0 1 K199‑ub KRWRHQLkAFHDQEG
0 1 K255‑ub GSGGGTLkYVEDVTN
0 7 K270‑ub VVRRDVEkWGPFDLV
0 2 Y295 CDRCPGWYMFQFHRI
0 2 Y305 QFHRILQYALPRQES
0 1 T340‑p TTTRFLQtEAVTLQD
0 1 S361 QNAMRVWSNIPGLKS
0 9 K376‑ub KHAPLTPkEEEYLQA
0 1 K390 AQVRSRSKLDAPkVD
0 3 K390‑ub AQVRSRSkLDAPkVD
0 3 K395‑ub RSkLDAPkVDLLVKN
  human

► Hide Isoforms
 
- gap
- gap
S27 VGSSELSSSVSPGTG
K165 RKWRSQLKAFYDRES
K219 GSDPGQLKHVVDVTD
E234 TVRKDVEEWGPFDLV
Y259‑p CDRPPSWyLFQFHRL
Y269‑p QFHRLLQyARPKPGS
M304 VASRFLEMEPVTIPD
S325 QNAVRVWSNIPAIRS
E340 RHWALVSEEELSLLA
K354‑m2 AQNKQSSkLAAKWPT
K354 AQNKQSSKLAAKWPT
W359 SSkLAAKWPTKLVKN
  DNMT3L iso2  
- gap
- gap
S27 VGSSELSSSVSPGTG
K165 RKWRSQLKAFYDRES
K219 GSDPGQLKHVVDVTD
E234 TVRKDVEEWGPFDLV
Y259 CDRPPSWYLFQFHRL
Y269 QFHRLLQYARPKPGS
M304 VASRFLEMEPVTIPD
S325‑p QNAVRVWsNIPAIRS
E341 RHWALVSEEELSLLA
K355 AQNKQSSKLAAKWPT
K355 AQNKQSSKLAAKWPT
W360 SSKLAAKWPTKLVKN
  rat

 
K12 ETPSSCSKTHETLNL
K45 PKSAPDLKEEDSMDM
T62 EDSKEPLTPSSPPTG
K200 KKWRHQLKAFHDREG
K256 GSEGGTLKYVEDVTN
K271 VVRREVEKWGPFDLV
Y296 CDRCPGWYMFQFHRI
Y306 QFHRILQYARPRQDS
T341 TTVRFLQTEAVTLQD
S362 QNAMRVWSNIPGLKS
K377 KHADLTPKEEQSLQT
K391 TQVRTRSKLAAQKVD
K391 TQVRTRSKLAAQKVD
K396 RSKLAAQKVDSLVKY
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