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Protein Page:
SNCA (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SNCA a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Cellular Component: actin cytoskeleton; axon; cell cortex; cell junction; cytoplasm; cytoplasmic vesicle membrane; cytoskeleton; cytosol; extracellular region; extracellular space; fibril; Golgi apparatus; growth cone; inclusion body; intracellular membrane-bound organelle; membrane; mitochondrion; nerve terminal; nuclear outer membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane; ribosome; rough endoplasmic reticulum; synapse; synaptic vesicle; terminal button
Molecular Function: alpha-tubulin binding; arachidonic acid binding; beta-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; dynein binding; enzyme binding; ferrous iron binding; histone binding; identical protein binding; kinesin binding; magnesium ion binding; metal ion binding; microtubule binding; oxidoreductase activity; phospholipase binding; phospholipid binding; phosphoprotein binding; protein binding; protein domain specific binding; protein N-terminus binding; tau protein binding; zinc ion binding
Biological Process: adult locomotory behavior; behavioral response to cocaine; caspase activation; dopamine biosynthetic process; dopamine metabolic process; fatty acid metabolic process; microglial cell activation; mitochondrial membrane organization and biogenesis; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of dopamine metabolic process; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of neuron apoptosis; negative regulation of norepinephrine uptake; negative regulation of protein amino acid phosphorylation; negative regulation of serotonin uptake; negative regulation of transporter activity; neutral lipid metabolic process; organelle ATP synthesis coupled electron transport; phospholipid metabolic process; positive regulation of endocytosis; positive regulation of neurotransmitter secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of synaptic transmission; protein destabilization; receptor internalization; regulation of acyl-CoA biosynthetic process; regulation of dopamine secretion; regulation of excitatory postsynaptic membrane potential; regulation of glutamate secretion; regulation of locomotion; regulation of long-term neuronal synaptic plasticity; regulation of macrophage activation; regulation of neuron apoptosis; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; response to drug; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synapse organization and biogenesis; synaptic transmission; synaptic transmission, dopaminergic; synaptic vesicle endocytosis; synaptic vesicle transport
Reference #:  O55042 (UniProtKB)
Alt. Names/Synonyms: alpha SYN; Alpha-synuclein; alphaSYN; NACP; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; Snca; Syn; synuclein, alpha; SYUA
Gene Symbols: Snca
Molecular weight: 14,485 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SNCA

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S129‑p
protein stabilization: S129‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K6 __MDVFMKGLSKAkE
0 1 K6‑ub __MDVFMkGLSKAkE
1 0 K6 __MDVFMKGLSKAkE
1 0 K10 VFMkGLSKAkEGVVA
0 1 K12‑m1 MkGLSKAkEGVVAAA
0 1 K12 MkGLSKAKEGVVAAA
1 0 K12 MkGLSKAKEGVVAAA
0 1 K21 GVVAAAEKTKQGVAE
1 0 K21 GVVAAAEKTKQGVAE
0 3 K23 VAAAEKTKQGVAEAA
1 0 K23 VAAAEKTKQGVAEAA
1 0 K34 AEAAGKTKEGVLyVG
2 12 Y39‑p KTKEGVLyVGsKTkE
0 5 S42‑p EGVLyVGsKTkEGVV
0 2 K43 GVLyVGsKTkEGVVH
0 1 K45 LyVGsKTKEGVVHGV
0 1 K45‑m1 LyVGsKTkEGVVHGV
1 0 K45 LyVGsKTKEGVVHGV
0 1 T54‑gl GVVHGVTtVAEKtKE
0 1 T54 GVVHGVTTVAEKtKE
0 1 K58 GVTtVAEKtKEQVTN
0 1 T59‑gl VTtVAEKtKEQVTNV
1 0 K60 TtVAEKtKEQVTNVG
1 1 T72‑gl NVGGAVVtGVTAVAQ
1 0 K80 GVTAVAQKTVEGAGN
5 1 N87 KTVEGAGNIAAATGF
0 1 N87 KTVEGAGNIAAATGF
0 1 K96 AAATGFVKKDQMGKG
0 1 K96‑ub AAATGFVkKDQMGKG
3 0 K96 AAATGFVKKDQMGKG
3 0 K102 VkKDQMGKGEEGYPQ
7 0 Y125 VDPGSEAYEMPsEEG
38 3 S129‑p SEAYEMPsEEGYQDY
2 0 Y133 EMPsEEGYQDYEPEA
2 0 Y136 sEEGYQDYEPEA___
23706 : Phospho-alpha-Synuclein (Ser129) (D1R1R) Rabbit mAb
  human

 
K6 __MDVFMKGLSkAkE
K6 __MDVFMKGLSkAkE
K6‑sm __MDVFMkGLSkAkE
K10‑sm VFMkGLSkAkEGVVA
K12 MkGLSkAKEGVVAAA
K12‑ub MkGLSkAkEGVVAAA
K12‑sm MkGLSkAkEGVVAAA
K21‑ub GVVAAAEkTkQGVAE
K21‑sm GVVAAAEkTkQGVAE
K23‑ub VAAAEkTkQGVAEAA
K23‑sm VAAAEkTkQGVAEAA
K34‑sm AEAAGKTkEGVLyVG
Y39‑p KTkEGVLyVGsKTkE
S42‑p EGVLyVGsKTkEGVV
K43 GVLyVGsKTkEGVVH
K45 LyVGsKTKEGVVHGV
K45 LyVGsKTKEGVVHGV
K45‑sm LyVGsKTkEGVVHGV
T54 GVVHGVATVAEkTkE
T54‑ga GVVHGVAtVAEkTkE
K58‑ac GVAtVAEkTkEQVTN
T59 VAtVAEkTkEQVTNV
K60‑sm AtVAEkTkEQVTNVG
T72 NVGGAVVTGVTAVAQ
K80‑sm GVTAVAQkTVEGAGs
S87‑p kTVEGAGsIAAATGF
S87‑gl kTVEGAGsIAAATGF
K96‑ac AAATGFVkKDQLGkN
K96 AAATGFVKKDQLGkN
K96‑sm AAATGFVkKDQLGkN
K102‑sm VkKDQLGkNEEGAPQ
Y125‑p VDPDNEAyEMPsEEG
S129‑p NEAyEMPsEEGyQDy
Y133‑p EMPsEEGyQDyEPEA
Y136‑p sEEGyQDyEPEA___
23706 : Phospho-alpha-Synuclein (Ser129) (D1R1R) Rabbit mAb
  rat

 
K6‑ac __MDVFMkGLSKAKE
K6 __MDVFMKGLSKAKE
K6 __MDVFMKGLSKAKE
K10 VFMkGLSKAKEGVVA
K12 MkGLSKAKEGVVAAA
K12 MkGLSKAKEGVVAAA
K12 MkGLSKAKEGVVAAA
K21 GVVAAAEKTKQGVAE
K21 GVVAAAEKTKQGVAE
K23 VAAAEKTKQGVAEAA
K23 VAAAEKTKQGVAEAA
K34 AEAAGKTKEGVLyVG
Y39‑p KTKEGVLyVGskTkE
S42‑p EGVLyVGskTkEGVV
K43‑ub GVLyVGskTkEGVVH
K45‑ac LyVGskTkEGVVHGV
K45 LyVGskTKEGVVHGV
K45 LyVGskTKEGVVHGV
T54 GVVHGVTTVAEKTKE
T54 GVVHGVTTVAEKTKE
K58 GVTTVAEKTKEQVTN
T59 VTTVAEKTKEQVTNV
K60 TTVAEKTKEQVTNVG
T72‑gl NVGGAVVtGVTAVAQ
K80 GVTAVAQKTVEGAGN
N87 KTVEGAGNIAAATGF
N87 KTVEGAGNIAAATGF
K96 AAATGFVKKDQMGKG
K96 AAATGFVKKDQMGKG
K96 AAATGFVKKDQMGKG
K102 VKKDQMGKGEEGYPQ
Y125 VDPSSEAYEMPSEEG
S129 SEAYEMPSEEGYQDY
Y133 EMPSEEGYQDYEPEA
Y136 SEEGYQDYEPEA___
23706 : Phospho-alpha-Synuclein (Ser129) (D1R1R) Rabbit mAb
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