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Protein Page:
ARHGAP3 (human)

Overview
ARHGAP3 GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAPs; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: 7p15.3
Cellular Component: cytoplasm; cytosol; membrane
Molecular Function: GTPase activator activity; metal ion binding; protein binding; SH3/SH2 adaptor activity
Biological Process: positive regulation of GTPase activity; positive regulation of signal transduction; regulation of small GTPase mediated signal transduction
Reference #:  P52757 (UniProtKB)
Alt. Names/Synonyms: ARHGAP3; BCH; beta chimerin; Beta-chimaerin; Beta-chimerin; chimerin (chimaerin) 2; CHIO; CHN2; MGC138360; Rho GTPase-activating protein 3; rho-GTPase-activating protein 3; RHOGAP3
Gene Symbols: CHN2
Molecular weight: 53,924 Da
Basal Isoelectric point: 7.04  Predict pI for various phosphorylation states
Select Structure to View Below

ARHGAP3

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Sites Implicated In
cell motility, altered: Y21‑p, S171‑p
cytoskeletal reorganization: Y153‑p
activity, inhibited: Y21‑p, Y153‑p, S171‑p
intracellular localization: Y153‑p, S171‑p
molecular association, regulation: S171‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S12‑p SNSSLSGsSVSSDAE
1 0 Y21‑p VSSDAEEyQPPIWKS
1 147 Y153‑p KMTTNPIyEHIGyAt
0 18 Y158‑p PIyEHIGyAtLLREK
0 7 T160‑p yEHIGyAtLLREKVs
1 0 S167‑p tLLREKVsRRLsRsK
1 1 S171‑p EKVsRRLsRsKNEPR
1 0 S173‑p VsRRLsRsKNEPRKT
0 4 N181 KNEPRKTNVTHEEHT
0 1 T188 NVTHEEHTAVEKIsS
0 1 S194‑p HTAVEKIsSLVRRAA
0 1 Y211 HNDNHFNYEKTHNFK
0 1 T349‑p YPDINIItGALKLYF
  mouse

► Hide Isoforms
 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S58 LFACSQISSLVRRAA
Y75 HNDNHFNYEKTHNFK
T213 YPDINIITGALKLYF
  ARHGAP3 iso5  
S12 SNSSLSGSSVSSDAE
Y21 VSSDAEEYQPPIWKS
Y153‑p KMTTNPIyEHIGYAT
Y158 PIyEHIGYATLLREK
T160 yEHIGYATLLREKVS
S167 TLLREKVSRRLsRSK
S171‑p EKVSRRLsRSKNESR
S173 VSRRLsRSKNESRKA
S181‑p KNESRKAsVSNEEHt
T188‑p sVSNEEHtPVEKISS
S194 HtPVEKISSLVRRAA
Y211‑p HNDNHFNyEKTHNFK
T349 YPDINIITGALKLYF
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