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Protein Page:
WDR5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WDR5 a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: histone acetyltransferase complex; histone methyltransferase complex; nucleoplasm; nucleus
Molecular Function: histone acetyltransferase activity (H4-K16 specific); histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; methylated histone residue binding; protein binding
Biological Process: histone H3-K4 methylation; neurite development; skeletal development; transcription, DNA-dependent
Reference #:  P61964 (UniProtKB)
Gene Symbols: WDR5
Molecular weight: 36,588 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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WDR5

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K7 _MATEEKKPETEAAR
0 2 T18‑p EAARAQPtPSSSATQ
0 1 K27 SSSATQSKPtPVkPN
0 3 K27‑ub SSSATQSkPtPVkPN
0 1 T29‑p SATQSkPtPVkPNYA
0 1 K32‑ub QSkPtPVkPNYALKF
0 1 S54‑p AVSSVKFsPNGEWLA
0 2 K112‑ac ASDDKTLkIWDVSSG
0 9 K120‑ub IWDVSSGkCLKTLKG
0 2 Y131‑p TLKGHSNyVFCCNFN
0 3 K159‑ub SVRIWDVkTGKCLKT
0 2 K227‑ub VKFSPNGkyILAATL
0 2 Y228‑p KFSPNGkyILAATLD
  mouse

 
K7 _MATEEKKPETEAAR
T18 EAARAQPTPSSSATQ
K27 SSSATQSKPTPVKPN
K27‑ub SSSATQSkPTPVKPN
T29 SATQSkPTPVKPNYA
K32 QSkPTPVKPNYALKF
S54 AVSSVKFSPNGEWLA
K112 ASDDKTLKIWDVSSG
K120‑ub IWDVSSGkCLKTLKG
Y131 TLKGHSNYVFCCNFN
K159‑ub SVRIWDVkTGKCLKT
K227‑ub VKFSPNGkYILAATL
Y228 KFSPNGkYILAATLD
  rat

 
K7‑ac _MATEEKkPETEAAR
T18 EAARAQPTPSSSATQ
K27‑ac SSSATQSkPTPVKPN
K27 SSSATQSKPTPVKPN
T29 SATQSkPTPVKPNYA
K32 QSkPTPVKPNYALKF
S54 AVSSVKFSPNGEWLA
K112 ASDDKTLKIWDVSSG
K120 IWDVSSGKCLKTLKG
Y131 TLKGHSNYVFCCNFN
K159 SVRIWDVKTGKCLKT
K227 VKFSPNGKYILAATL
Y228 KFSPNGKYILAATLD
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