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Protein Page:
IL17RA (human)

Overview
IL17RA Receptor for IL17A and IL17F. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 22q11.1
Cellular Component: extracellular region; integral to plasma membrane; plasma membrane
Molecular Function: interleukin-17 receptor activity; protein binding; receptor binding
Biological Process: cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; defense response to fungus; positive regulation of interleukin-23 production
Disease: Candidiasis, Familial, 5
Reference #:  Q96F46 (UniProtKB)
Alt. Names/Synonyms: CD217; CDw217; hIL-17R; I17RA; IL-17 receptor A; IL-17RA; IL17R; IL17RA; interleukin 17 receptor A; Interleukin-17 receptor A; MGC10262
Gene Symbols: IL17RA
Molecular weight: 96,122 Da
Basal Isoelectric point: 5.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IL17RA

Protein Structure Not Found.
Download PyMol Script
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Sites Implicated In
protein degradation: T780‑p
ubiquitination: T780‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S264‑p PEEFHQRsNVTLTLR
0 2 I371 GLPAADLIPPPLKPR
1 1 S554‑p MHRVGELsGDNYLRS
0 1 S600 ADDQDAPSLDEEVFE
1 22 S629‑p PLVREPGsQACLAID
1 8 S708‑p EACPLLGsPGAGRNS
1 1 S726‑p LPVDPEDsPLGSSTP
0 1 S736 GSSTPMASPDLLPED
1 2 T780‑p MVLTDPHtPYEEEQR
1 1 S792‑p EQRQSVQsDQGyIsR
0 12 Y796‑p SVQsDQGyIsRSsPQ
1 1 S798‑p QsDQGyIsRSsPQPP
1 1 S801‑p QGyIsRSsPQPPEGL
  mouse

 
A264 QEEFHQRANVTFTLS
T373‑p ILPVADLtPPPLRPR
T557 MHHVRELTGDNYLQS
S603‑p ADGQDLPsLDEEVFE
S632 PLVRELPSDGCLVVD
V712 EACPLLGVQRNSILC
L727 LPVDSDDLPLCSTPM
S736‑p LCSTPMMsPDHLQGD
T779‑p EVVLEGCtPSEEEQR
S791 EQRQSVQSDQGYISR
Y795 SVQSDQGYISRSSPQ
S797 QSDQGYISRSSPQPP
S800 QGYISRSSPQPPEWL
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