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Protein Page:
CASP10 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CASP10 Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10. Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon. Belongs to the peptidase C14A family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.22.63; Protease
Chromosomal Location of Human Ortholog: 2q33-q34
Cellular Component: CD95 death-inducing signaling complex; cytosol
Molecular Function: cysteine-type endopeptidase activity; protein binding; ubiquitin protein ligase binding
Biological Process: apoptosis; cell surface receptor linked signal transduction; induction of apoptosis via death domain receptors; macrophage differentiation; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of apoptosis
Disease: Autoimmune Lymphoproliferative Syndrome, Type Iia; Gastric Cancer; Lymphoma, Non-hodgkin, Familial
Reference #:  Q92851 (UniProtKB)
Alt. Names/Synonyms: ALPS2; Apoptotic protease Mch-4; CASP-10; CASP10; CASPA; caspase 10, apoptosis-related cysteine peptidase; caspase 10, apoptosis-related cysteine protease; Caspase-10; Caspase-10 subunit p12; Caspase-10 subunit p23/17; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; MCH4
Gene Symbols: CASP10
Molecular weight: 58,951 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CASP10

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 14 Y9‑p KSQGQHWySSSDKNC
0 1 K99‑ub LQHLNCTkEEVERLL
0 1 K158‑ub SFLAFLEkQGKIDED
0 2 T198‑p EKAIQIVtPPVDKEA
0 1 S216‑p QGEEELVsQTDVKTF
0 1 S260‑p SRGMQGAsANTLNSE
0 1 T268‑p ANTLNSEtSTkRAAV
0 1 K271‑ub LNSEtSTkRAAVYRM
0 1 K338‑ub EMEMVLQkQKCNPAH
  CASP10 iso2  
Y9 KSQGQHWYSSSDKNC
K99 LQHLNCTKEEVERLL
K158 SFLAFLEKQGKIDED
T198 EKAIQIVTPPVDKEA
S216 QGEEELVSQTDVKTF
- gap
- gap
- gap
K295 EMEMVLQKQKCNPAH
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