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Protein Page:
MKP-5 (human)

MKP-5 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: cytoplasm; Golgi apparatus; nucleoplasm; nucleus
Molecular Function: MAP kinase phosphatase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity
Biological Process: dephosphorylation; inactivation of MAPK activity; JNK cascade; negative regulation of JNK activity; protein amino acid dephosphorylation; response to stress
Reference #:  Q9Y6W6 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 10; dual specificity phosphatase MKP-5; Dual specificity protein phosphatase 10; DUS10; DUSP10; MAP kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; MKP-5; MKP5; serine/threonine specific protein phosphatase
Gene Symbols: DUSP10
Molecular weight: 52,642 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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