a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: EC 18.104.22.168; Protein phosphatase, dual-specificity; EC 22.214.171.124; Motility/polarity/chemotaxis
Biological Process: inactivation of MAPK activity; JNK cascade; negative regulation of JNK activity; negative regulation of oligodendrocyte differentiation; oligodendrocyte differentiation; protein amino acid dephosphorylation; regulation of adaptive immune response; response to lipopolysaccharide; response to stress
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.