an intracellular protein that binds to actin and cortactin, and possesses tumor suppressor activity. Binds to the cytoplasmic domain of receptor protein tyrosine phosphatase delta. Senses and induces curved membranous curvatures important for cellular polarization, mobilization and endocytosis. May be related to cancer progression or tumor metastasis in a variety of organ sites. Its expression is down-regulated by MiR-135a. Downregulated in prostate cancer. Expressed in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood. Belongs to the MTSS1 family. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor
Molecular Function: actin monomer binding; identical protein binding; protein binding; receptor binding
Biological Process: actin cytoskeleton organization and biogenesis; negative regulation of epithelial cell proliferation; positive regulation of defense response to virus by host; transmembrane receptor protein tyrosine kinase signaling pathway