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Protein Page:
RAGE (human)

RAGE Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Interacts with S100B, S100A1 and APP. Interacts with S100A12. Endothelial cells. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; receptor activity; transmembrane receptor activity
Biological Process: activation of NF-kappaB transcription factor; cell surface receptor linked signal transduction; innate immune response; negative regulation of interleukin-10 production; neurite development; positive regulation of activated T cell proliferation; positive regulation of interleukin-12 production; regulation of T cell mediated cytotoxicity; response to wounding
Reference #:  Q15109 (UniProtKB)
Alt. Names/Synonyms: advanced glycosylation end product-specific receptor; AGER; MGC22357; RAGE; receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products
Gene Symbols: AGER
Molecular weight: 42,803 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
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