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Protein Page:
MKP-3 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKP-3 a non-receptor, dual-specificity phosphoprotein phosphatase. Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 12q22-q23
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process: activation of MAPK activity; activation of MAPKK activity; axon guidance; dorsal/ventral pattern formation; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; inactivation of MAPK activity; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; Ras protein signal transduction; regulation of endodermal cell fate specification; regulation of fibroblast growth factor receptor signaling pathway; response to drug; response to nitrosative stress; response to organic cyclic substance; small GTPase mediated signal transduction; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Disease: Hypogonadotropic Hypogonadism 19 With Or Without Anosmia
Reference #:  Q16828 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 6; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6; DUSP6; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP-3; MKP3; PYST1; serine/threonine specific protein phosphatase
Gene Symbols: DUSP6
Molecular weight: 42,320 Da
Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKP-3

Protein Structure Not Found.


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Sites Implicated In
protein degradation: S159‑p, S174‑p, S197‑p

Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K68‑ub IMLRRLQkGNLPVRA
4 0 S159‑p DGSCSSSsPPLPVLG
1 0 S174‑p LGGLRISsDSSsDIE
0 1 S178‑p RISsDSSsDIEsDLD
0 1 S182‑p DSSsDIEsDLDRDPN
4 0 S197‑p SATDSDGsPLSNSQP
0 5 K254‑ub FENAGEFkyKQIPIS
0 1 Y255‑p ENAGEFkyKQIPISD
1 0 S300‑p CLAGISRsVTVTVAY
0 2 K324‑ub NDAYDIVkMKKsNIs
0 7 S328‑p DIVkMKKsNIsPNFN
0 16 S331‑p kMKKsNIsPNFNFMG
0 2 S351‑p ERTLGLSsPCDNRVP
  mouse

 
K68 IMLRRLQKGNLPVRA
S159‑p DGSCSSSsPPLPVLG
S174 LGGLRISSDSSSDIE
S178 RISSDSSSDIESDLD
S182 DSSSDIESDLDRDPN
S197‑p SATDSDGsPLSNSQP
K254 FENAGEFKYKQIPIS
Y255 ENAGEFKYKQIPISD
S300 CLAGISRSVTVTVAY
K324 NDAYDIVKMKKsNIs
S328‑p DIVKMKKsNIsPNFN
S331‑p KMKKsNIsPNFNFMG
S351 ERTLGLSSPCDNRVP
  rat

 
K68 IMLRRLQKGNLPVRA
S159 DGSCSSSSPPLPVLG
S174 LGGLRISSDSSSDIE
S178 RISSDSSSDIESDLD
S182 DSSSDIESDLDRDPN
S197 SATDSDGSPLSNSQP
K254 FENAGEFKYKQIPIS
Y255 ENAGEFKYKQIPISD
S300 CLAGISRSVTVTVAY
K324 NDAYDIVKMKKSNIs
S328 DIVKMKKSNIsPNFN
S331‑p KMKKSNIsPNFNFMG
S351 ERTLGLSSPCDNRVP
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