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Protein Page:
MKP-3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MKP-3 a non-receptor, dual-specificity phosphoprotein phosphatase. Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q22-q23
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process: activation of MAPK activity; cell differentiation; dorsal/ventral pattern formation; inactivation of MAPK activity; MAPKKK cascade; positive regulation of apoptosis; regulation of endodermal cell fate specification; regulation of fibroblast growth factor receptor signaling pathway; response to drug; response to nitrosative stress; response to organic cyclic substance
Disease: Hypogonadotropic Hypogonadism 19 With Or Without Anosmia
Reference #:  Q16828 (UniProtKB)
Gene Symbols: DUSP6
Molecular weight: 42,320 Da
Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MKP-3

Protein Structure Not Found.
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Sites Implicated In
protein degradation: S159‑p, S174‑p, S197‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K68‑ub IMLRRLQkGNLPVRA
4 0 S159‑p DGSCSSSsPPLPVLG
1 0 S174‑p LGGLRISsDSSsDIE
0 1 S178‑p RISsDSSsDIEsDLD
0 1 S182‑p DSSsDIEsDLDRDPN
4 0 S197‑p SATDSDGsPLSNSQP
0 5 K254‑ub FENAGEFkyKQIPIS
0 1 Y255‑p ENAGEFkyKQIPISD
1 0 S300‑p CLAGISRsVTVTVAY
0 2 K324‑ub NDAYDIVkMKKsNIs
0 7 S328‑p DIVkMKKsNIsPNFN
0 17 S331‑p kMKKsNIsPNFNFMG
0 2 S351‑p ERTLGLSsPCDNRVP
  mouse

 
K68 IMLRRLQKGNLPVRA
S159‑p DGSCSSSsPPLPVLG
S174 LGGLRISSDSSSDIE
S178 RISSDSSSDIESDLD
S182 DSSSDIESDLDRDPN
S197‑p SATDSDGsPLSNSQP
K254 FENAGEFKYKQIPIS
Y255 ENAGEFKYKQIPISD
S300 CLAGISRSVTVTVAY
K324 NDAYDIVKMKKsNIs
S328‑p DIVKMKKsNIsPNFN
S331‑p KMKKsNIsPNFNFMG
S351 ERTLGLSSPCDNRVP
  rat

 
K68 IMLRRLQKGNLPVRA
S159 DGSCSSSSPPLPVLG
S174 LGGLRISSDSSSDIE
S178 RISSDSSSDIESDLD
S182 DSSSDIESDLDRDPN
S197 SATDSDGSPLSNSQP
K254 FENAGEFKYKQIPIS
Y255 ENAGEFKYKQIPISD
S300 CLAGISRSVTVTVAY
K324 NDAYDIVKMKKSNIs
S328 DIVKMKKSNIsPNFN
S331‑p KMKKSNIsPNFNFMG
S351 ERTLGLSSPCDNRVP
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