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Protein Page:
RRP8 (human)

Overview
RRP8 Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Belongs to the methyltransferase superfamily. RRP8 family. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.-; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: chromatin silencing complex; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane
Molecular Function: methylated histone residue binding; protein binding; S-adenosylmethionine-dependent methyltransferase activity
Biological Process: cellular response to glucose starvation; chromatin silencing at rDNA; regulation of transcription by glucose
Reference #:  O43159 (UniProtKB)
Alt. Names/Synonyms: Cerebral protein 1; KIAA0409; NML; Nucleomethylin; ribosomal RNA processing 8, methyltransferase, homolog (yeast); Ribosomal RNA-processing protein 8; RRP8; RRP8 methyltransferase homolog
Gene Symbols: RRP8
Molecular weight: 50,715 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RRP8

Protein Structure Not Found.
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