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Protein Page:
RRP8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RRP8 Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. Component of the eNoSC complex, composed of SIRT1, SUV39H1 and RRP8. Belongs to the methyltransferase superfamily. RRP8 family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Nucleolus; EC 2.1.1.-
Chromosomal Location of Human Ortholog: 11p15.4
Cellular Component: chromatin silencing complex; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane
Molecular Function: methylated histone residue binding; protein binding; S-adenosylmethionine-dependent methyltransferase activity
Biological Process: cellular response to glucose starvation; chromatin silencing at rDNA; regulation of transcription by glucose
Reference #:  O43159 (UniProtKB)
Alt. Names/Synonyms: Cerebral protein 1; KIAA0409; NML; Nucleomethylin; ribosomal RNA processing 8, methyltransferase, homolog (yeast); Ribosomal RNA-processing protein 8; RRP8; RRP8 methyltransferase homolog
Gene Symbols: RRP8
Molecular weight: 50,715 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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RRP8

Protein Structure Not Found.
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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T43‑p KRRQLLAtLRALEAA
0 1 S53‑p ALEAASLsQHPPsLC
0 14 S58‑p SLsQHPPsLCIsDsE
0 39 S62‑p HPPsLCIsDsEEEEE
0 39 S64‑p PsLCIsDsEEEEEER
0 1 K78‑ac RKKKCPKkAsFAsAs
0 3 S80‑p KKCPKkAsFAsAsAE
0 2 S83‑p PKkAsFAsAsAEVGK
0 1 S85‑p kAsFAsAsAEVGKKG
0 19 S104‑p QKQGPPCsDsEEEVE
0 19 S106‑p QGPPCsDsEEEVERK
0 4 S124‑p HKQALVGsDsAEDEK
0 9 S126‑p QALVGsDsAEDEKRK
0 1 K157‑sm NVDQTGPkAWKGstT
0 2 S162‑p GPkAWKGstTNDPPK
0 2 T163‑p PkAWKGstTNDPPKQ
0 1 T164 kAWKGstTNDPPKQs
0 9 S171‑p TNDPPKQsPGstsPK
0 2 S174‑p PPKQsPGstsPKPPH
0 3 T175‑p PKQsPGstsPKPPHT
0 11 S176‑p KQsPGstsPKPPHTL
0 2 P179 PGstsPKPPHTLSRK
0 1 K201‑sm NKRRCKNkFQPPQVP
0 16 S223‑p PTEKTEVsPVPRTDS
0 1 A233 PRTDSHEARAGALRA
0 2 S286‑p LYHRGFQsQVKKWPL
0 1 K440‑sm GPPLVGPkAQLSGLQ
0 1 K454‑sm QLQPCLYkRR_____
  mouse

 
T43 KRRHLLATLRALEAA
S53 ALEAASLSQQTPsLP
S58‑p SLSQQTPsLPGsDsE
S62‑p QTPsLPGsDsEEEEE
S64‑p PsLPGsDsEEEEEVG
R79 RKKRHLQRPSLASVS
S81 KRHLQRPSLASVSKE
S84 LQRPSLASVSKEVGK
S86 RPSLASVSKEVGKKR
S105‑p QKQAPSIsDSEGKEI
S107 QAPSIsDSEGKEIRR
G125 RQAPPLGGVSAGEEK
S127 APPLGGVSAGEEKGK
N158 SVDQTVHNSRTstAt
S162‑p TVHNSRTstAtIDPS
T163‑p VHNSRTstAtIDPSK
T165‑p NSRTstAtIDPSKPs
S172‑p tIDPSKPsPEsMsPN
S175‑p PSKPsPEsMsPNsSH
M176 SKPsPEsMsPNsSHT
S177‑p KPsPEsMsPNsSHTL
S180‑p PEsMsPNsSHTLSRK
K202 NKRRHKNKFRPLQTP
P224 SIEETEVPPVPKSDS
S234‑p PKSDSQEsRAGALRA
R287 LYHRGFQRQVKKWPL
K441 GPPRVGPKAQLSGLK
K455 KLQPCLYKRR_____
  rat

 
T43 KRRHLLATLRALEAA
S53 ALEAASLSQQCPSLP
S58 SLSQQCPSLPGsDsE
S62‑p QCPSLPGsDsEEEEE
S64‑p PSLPGsDsEEEEEVG
R79 RKKRHFQRSSLANVS
S81 KRHFQRSSLANVSKE
N84 FQRSSLANVSKEVGK
S86 RSSLANVSKEVGKKR
S105 QKQAPFISDSEGKEV
S107 QAPFISDSEGKEVER
G125 RQAPPLGGISAGEEK
S127 APPLGGISAGEEKGK
N158 SVDQTVHNSRTSTAT
S162 TVHNSRTSTATLDPP
T163 VHNSRTSTATLDPPK
T165 NSRTSTATLDPPKSS
S172 TLDPPKSSRESAsPN
S175 PPKSSRESAsPNSSH
A176 PKSSRESAsPNSSHT
S177‑p KSSRESAsPNSSHTL
S180 RESAsPNSSHTLSRK
K202 NKRRHKNKFRPLETQ
P224 SIEETEVPPAPKSDS
T234 PKSDSQETRAGALRA
R287 LYHRGFQRQVKKWPL
K441 GPPRVGPKAQLSGLK
K455 KLQPCLYKHR_____
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