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Protein Page:
MKP-1 (human)

MKP-1 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP1 specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation. It is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 5q34
Cellular Component: cytoplasm; nucleus
Molecular Function: MAP kinase tyrosine/serine/threonine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity
Biological Process: endoderm formation; inactivation of MAPK activity; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of meiotic cell cycle; regulation of apoptosis; response to oxidative stress
Reference #:  P28562 (UniProtKB)
Alt. Names/Synonyms: CL100; dual specificity phosphatase 1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUS1; DUSP1; HVH1; MAP kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 1; MKP-1; MKP1; Protein-tyrosine phosphatase CL100; PTPN10; serine/threonine specific protein phosphatase; VH1
Gene Symbols: DUSP1
Molecular weight: 39,298 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades
Select Structure to View Below


Protein Structure Not Found.

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