an AGC kinase of the PKC family. A classical PKC downstream of many mitogenic receptors. Activates the NF-kappaB signaling pathway in B cells after antigen-receptor signaling. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; Alpha subfamily; EC 220.127.116.11; Kinase, protein; Motility/polarity/chemotaxis; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: androgen receptor binding; calcium-dependent protein kinase C activity; chromatin binding; histone binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein kinase C activity; protein kinase C binding; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; B cell activation; B cell receptor signaling pathway; lipoprotein transport; mitotic nuclear envelope disassembly; negative regulation of insulin receptor signaling pathway; peptidyl-serine phosphorylation; platelet activation; positive regulation of angiogenesis; positive regulation of B cell receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of vascular endothelial growth factor receptor signaling pathway; protein amino acid phosphorylation; regulation of transcription from RNA polymerase II promoter