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Protein Page:
MCM7 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MCM7 Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6- MCM4-MCM7-MCM3-MCM5 (By simililarity). Interacts with the ATR- ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Belongs to the MCM family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.12; DNA replication; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q21.3-q22.1
Cellular Component: chromatin; cytoplasm; MCM complex; membrane; nuclear chromosome, telomeric region; nucleoplasm
Molecular Function: ATP-dependent DNA helicase activity; DNA binding; protein binding
Biological Process: DNA replication; G1/S transition of mitotic cell cycle; regulation of phosphorylation; response to DNA damage stimulus
Reference #:  P33993 (UniProtKB)
Alt. Names/Synonyms: CDC47; CDC47 homolog; DNA replication licensing factor MCM7; homolog of S. cerevisiae Cdc47; MCM2; MCM7; minichromosome maintenance complex component 7; minichromosome maintenance deficient 7; P1.1-MCM3; P1CDC47; P85MCM; PNAS146
Gene Symbols: MCM7
Molecular weight: 81,308 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MCM7

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K4 ____MALKDyALEkE
0 2 K4‑ub ____MALkDyALEkE
0 1 K4‑sm ____MALkDyALEkE
0 1 K4‑sc ____MALkDyALEkE
0 1 Y6‑p __MALkDyALEkEKV
0 7 K10‑ub LkDyALEkEKVKkFL
0 1 K10‑sm LkDyALEkEKVKkFL
0 1 K10‑sc LkDyALEkEKVKkFL
0 4 K15‑ub LEkEKVKkFLQEFyQ
0 1 K15‑sm LEkEKVKkFLQEFyQ
0 1 Y21‑p KkFLQEFyQDDELGk
0 10 K28‑ac yQDDELGkkQFkYGN
0 52 K28‑ub yQDDELGkkQFkYGN
0 1 K29‑ac QDDELGkkQFkYGNQ
0 22 K29‑ub QDDELGkkQFkYGNQ
0 3 K32‑ub ELGkkQFkYGNQLVR
0 1 K32‑sm ELGkkQFkYGNQLVR
0 4 K75‑ub ENARRYAkLFADAVQ
0 14 K89‑ub QELLPQYkEREVVNk
0 2 K96‑ub kEREVVNkDVLDVyI
0 1 Y102‑p NkDVLDVyIEHRLMM
0 1 S113‑p RLMMEQRsRDPGMVR
1 16 S121‑p RDPGMVRsPQNQYPA
0 60 K145‑ub FQGPSSNkPRVIREV
0 2 S156‑p IREVRADsVGkLVTV
0 16 K159‑ub VRADsVGkLVTVRGI
0 1 K159‑sm VRADsVGkLVTVRGI
0 1 T168‑p VTVRGIVtRVSEVkP
0 2 K174‑ub VtRVSEVkPKMVVAT
0 1 K174‑sm VtRVSEVkPKMVVAT
0 6 K231‑ub TRGSRFIkFQEMkMQ
0 1 K231‑sm TRGSRFIkFQEMkMQ
0 4 K236‑ub FIkFQEMkMQEHSDQ
0 1 K236‑sm FIkFQEMkMQEHSDQ
0 1 Y297‑p QGLLSETyLEAHRIV
0 1 K305‑ub LEAHRIVkMNksEDD
0 10 K308‑ub HRIVkMNksEDDEsG
0 1 K308‑sm HRIVkMNksEDDEsG
0 2 S309‑p RIVkMNksEDDEsGA
0 6 S314‑p NksEDDEsGAGELtR
0 4 T320‑p EsGAGELtREELRQI
0 1 R321 sGAGELtREELRQIA
0 2 Y333‑p QIAEEDFyEkLAASI
0 1 K335‑ub AEEDFyEkLAASIAP
0 2 K351‑ub IYGHEDVkkALLLLL
0 1 K351‑sc IYGHEDVkkALLLLL
0 3 K352‑ub YGHEDVkkALLLLLV
2 4 S365‑p LVGGVDQsPRGMKIR
0 25 K387‑ub MGDPGVAksQLLsYI
0 2 S388‑p GDPGVAksQLLsYID
0 2 S392‑p VAksQLLsYIDRLAP
0 1 T466 HEVMEQQTISIAkAG
0 1 S468 VMEQQTISIAkAGIL
0 4 K471‑ub QQTISIAkAGILTTL
0 13 Y492‑p LAAANPAyGRYNPRR
0 14 S500‑p GRYNPRRsLEQNIQL
0 1 T538‑p LRLAQHItyVHQHsR
0 1 Y539‑p RLAQHItyVHQHsRQ
0 1 S544‑p ItyVHQHsRQPPsQF
0 1 S549‑p QHsRQPPsQFEPLDM
0 5 K557‑ub QFEPLDMkLMRRYIA
0 7 K569‑ub YIAMCREkQPMVPES
0 17 K596‑ub RREAWASkDAtyTSA
0 1 T599‑p AWASkDAtyTSARtL
1 38 Y600‑p WASkDAtyTSARtLL
0 1 T605‑p AtyTSARtLLAILRL
0 18 K627‑ub RMVDVVEkEDVNEAI
0 5 K641‑ub IRLMEMSkDSLLGDk
0 18 K648‑ub kDSLLGDkGQTARTQ
0 1 S670‑p ATVRELVsGGRsVRF
0 3 S674‑p ELVsGGRsVRFsEAE
0 6 S678‑p GGRsVRFsEAEQRCV
  mouse

 
K4 ____MALKDYAIEKE
K4 ____MALKDYAIEKE
K4 ____MALKDYAIEKE
K4 ____MALKDYAIEKE
Y6 __MALKDYAIEKEKV
K10 LKDYAIEKEKVKKFL
K10 LKDYAIEKEKVKKFL
K10 LKDYAIEKEKVKKFL
K15 IEKEKVKKFLQEFYY
K15 IEKEKVKKFLQEFYY
Y21 KKFLQEFYYENELGk
K28 YYENELGKKQFkYGT
K28‑ub YYENELGkKQFkYGT
K29 YENELGkKQFkYGTQ
K29 YENELGkKQFkYGTQ
K32‑ub ELGkKQFkYGTQLVH
K32 ELGkKQFKYGTQLVH
R75 ENAKRYSRLFGDVVQ
K89 QELLPEYKEKEVVNK
K96 KEKEVVNKDVLDVYI
Y102 NKDVLDVYIEHRLMM
S113 RLMMEQRSRDPGAVR
N121 RDPGAVRNPQNQYPS
K145 FRGPSSSKPRVIREV
S156 IREVRADSVGKLLTV
K159 VRADSVGKLLTVRGI
K159 VRADSVGKLLTVRGI
T168 LTVRGIVTRVSEVKP
K174 VTRVSEVKPRMVVAT
K174 VTRVSEVKPRMVVAT
K231 TRGSKFVKFQEMKIQ
K231 TRGSKFVKFQEMKIQ
K236 FVKFQEMKIQEHSDQ
K236 FVKFQEMKIQEHSDQ
Y297 QGLLSETYLEAHWIV
K305 LEAHWIVKMTKSDDD
K308 HWIVKMTKSDDDVsG
K308 HWIVKMTKSDDDVsG
S309 WIVKMTKSDDDVsGA
S314‑p TKSDDDVsGAGELSs
S320 VsGAGELSsEELKQI
S321‑p sGAGELSsEELKQIA
Y333 QIAEEDFYEKLAASI
K335 AEEDFYEKLAASIAP
K351 IYGHEDVKKALLLLL
K351 IYGHEDVKKALLLLL
K352 YGHEDVKKALLLLLV
S365 LVGGVDQSPQGMKIR
K387 MGDPGVAKsQLLSYI
S388‑p GDPGVAKsQLLSYID
S392 VAKsQLLSYIDRLAP
T466‑p HEVMEQQtIsIAKAG
S468‑p VMEQQtIsIAKAGIL
K471 QQtIsIAKAGILTTL
Y492‑p LAAANPAyGRYNPRR
S500‑p GRYNPRRsLEQNVQL
T538 LRLAQHITYVHQHSR
Y539 RLAQHITYVHQHSRQ
S544 ITYVHQHSRQPPAQF
A549 QHSRQPPAQFEPLDM
K557 QFEPLDMKLMRRYIA
R569 YIAMCHERQPTVPES
K596 RREARASKDATYTSA
T599 ARASKDATYTSARTL
Y600 RASKDATYTSARTLL
T605 ATYTSARTLLAILRL
K627 RMVDIVEKEDVNEAI
K641 IRLMEMSKDSLLGEk
K648‑ub KDSLLGEkGQTARTQ
S670 ATIRELVSRGRsVHF
S674‑p ELVSRGRsVHFSEAE
S678 RGRsVHFSEAEQRCI
  rat

 
K4‑ac ____MALkDYAIEKE
K4 ____MALKDYAIEKE
K4 ____MALKDYAIEKE
K4 ____MALKDYAIEKE
Y6 __MALkDYAIEKEKV
K10 LkDYAIEKEKVKKFL
K10 LkDYAIEKEKVKKFL
K10 LkDYAIEKEKVKKFL
K15 IEKEKVKKFLQEFYY
K15 IEKEKVKKFLQEFYY
Y21 KKFLQEFYYDDELGK
K28 YYDDELGKKQFKYGT
K28 YYDDELGKKQFKYGT
K29 YDDELGKKQFKYGTQ
K29 YDDELGKKQFKYGTQ
K32 ELGKKQFKYGTQLVH
K32 ELGKKQFKYGTQLVH
R75 ENAKRYSRLFADVVQ
K89 QELLPEYKEKEVVNK
K96 KEKEVVNKDVLDVYI
Y102 NKDVLDVYIEHRLMM
S113 RLMMEQRSRDPGAVR
N121 RDPGAVRNPQNQYPS
K145 FQGPSSSKPRVIREV
S156 IREVRADSVGKLLTV
K159 VRADSVGKLLTVRGI
K159 VRADSVGKLLTVRGI
T168 LTVRGIVTRVSEVKP
K174 VTRVSEVKPRMVVAT
K174 VTRVSEVKPRMVVAT
K231 TRGSKFIKFQEMKIQ
K231 TRGSKFIKFQEMKIQ
K236 FIKFQEMKIQEHSDQ
K236 FIKFQEMKIQEHSDQ
Y297 QGLLSETYLEAHRVV
K305 LEAHRVVKMTKSEDD
K308 HRVVKMTKSEDDVSG
K308 HRVVKMTKSEDDVSG
S309 RVVKMTKSEDDVSGA
S314 TKSEDDVSGAGELSA
S320 VSGAGELSAEELKQI
A321 SGAGELSAEELKQIA
Y333 QIAEEDFYEKLAASI
K335 AEEDFYEKLAASIAP
K351 IYGHEDVKKALLLLL
K351 IYGHEDVKKALLLLL
K352 YGHEDVKKALLLLLV
S365 LVGGVDQSPQGMKIR
K387 MGDPGVAKSQLLSYI
S388 GDPGVAKSQLLSYID
S392 VAKSQLLSYIDRLAP
T466 HEVMEQQTISIAKAG
S468 VMEQQTISIAKAGIL
K471 QQTISIAKAGILTTL
Y492 LAAANPAYGRYNPRR
S500‑p GRYNPRRsLEQNIQL
T538 LRLAQHITYVHQHSR
Y539 RLAQHITYVHQHSRQ
S544 ITYVHQHSRQPPAQF
A549 QHSRQPPAQFEPLDM
K557 QFEPLDMKLMRRYIA
R569 YIAMCRERQPTVPDS
K596 RREARASKDATYTSA
T599 ARASKDATYTSARTL
Y600 RASKDATYTSARTLL
T605 ATYTSARTLLAILRL
K627 RMVDIVEKEDVNEAI
K641 IRLMEMSKDSLLGEK
K648 KDSLLGEKGQTARTQ
S670 ATVRELVSGGRSVRF
S674 ELVSGGRSVRFSEAE
S678 GGRSVRFSEAEQRCI
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