a transcription factor of the Sp1 C2H2-type zinc-finger protein family. Phosphorylated and activated by MAPK. Dephosphorylation by PTEN inhibits DNA binding. Binds to p38 in the nucleus. Interacts with Huntingtin and TAFII130. Transcriptional activity of SP1 and TAFII130 disrupted in early Huntingtin's Disease. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Molecular Function: bHLH transcription factor binding; DNA binding; double-stranded DNA binding; histone acetyltransferase binding; histone deacetylase binding; metal ion binding; protein binding; protein C-terminus binding; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity; transcription factor binding
Biological Process: embryonic camera-type eye morphogenesis; embryonic placenta development; embryonic process involved in female pregnancy; embryonic skeletal development; enucleate erythrocyte differentiation; gene expression; liver development; lung development; megakaryocyte differentiation; ossification; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; rhythmic process; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; trophectodermal cell differentiation; viral reproduction
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.