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Protein Page:
NLRC4 (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NLRC4 Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: cytosol; intracellular; nucleus; spindle microtubule
Molecular Function: ATP binding; cysteine protease inhibitor activity; identical protein binding; magnesium ion binding; protein binding; protein homodimerization activity; ubiquitin-protein ligase activity
Biological Process: activation of innate immune response; activation of NF-kappaB transcription factor; caspase activation; defense response to bacterium; detection of bacterium; inflammatory response; innate immune response; interleukin-1 beta secretion; positive regulation of apoptosis; protein homooligomerization; protein ubiquitination; regulation of signal transduction
Disease: Autoinflammation With Infantile Enterocolitis; Familial Cold Autoinflammatory Syndrome 4
Reference #:  Q9NPP4 (UniProtKB)
Alt. Names/Synonyms: CARD, LRR, and NACHT-containing protein; CARD12; caspase recruitment domain family, member 12; Caspase recruitment domain-containing protein 12; CLAN; Clan protein; CLAN1; CLANA; CLANB; CLANC; CLAND; CLR2.1; Ice protease-activating factor; ICE-protease activating factor; IPAF; NLR family CARD domain-containing protein 4; NLR family, CARD domain containing 4; NLRC4; NOD-like receptor C4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Gene Symbols: NLRC4
Molecular weight: 116,159 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NLRC4

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T195 SGKCKALTKFKFVFF
0 1 K315‑ac LIREVLIkELAEGLL
1 1 S533 RPLWRQESLQSVKNT
0 1 T736‑p ERHITSVtNLKTLSI
  mouse

 
K195‑ac SGGCRALkGFRLVFF
P315 LIEAVLVPDQVERLW
S533‑p RPLWRQEsIQSLRNT
T736 EQYITSVTGLQNLSI
  rat

 
N195 SGMCPALNQFKLVFF
N315 LIREVLINELAEGLL
S533 RPLWRQESIQNLRNT
T735 EQYITSVTDLQNLSI
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