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Protein Page:
RAC2 (human)

RAC2 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. Interacts with DOCK2, which may activate it. Hematopoietic specific. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Belongs to the small GTPase superfamily. Rho family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: actin filament; cytosol; focal adhesion; lamellipodium; phagocytic vesicle membrane; plasma membrane
Molecular Function: GTP binding
Biological Process: actin filament organization; platelet activation; regulation of hydrogen peroxide metabolic process; regulation of small GTPase mediated signal transduction; signal transduction
Disease: Neutrophil Immunodeficiency Syndrome
Reference #:  P15153 (UniProtKB)
Alt. Names/Synonyms: EN-7; GX; HSPC022; p21-Rac2; RAC2; Ras-related C3 botulinum toxin substrate 2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); rho family, small GTP binding protein Rac2; Small G protein
Gene Symbols: RAC2
Molecular weight: 21,429 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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