Required for initiation of chromosomal DNA replication. Associated with ORC2. Widely expressed, highest levels are found in adult testis and thymus and in fetal liver. Belongs to the CDC45 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: 3'-5' DNA helicase activity; chromatin binding; DNA replication origin binding; protein binding; single-stranded DNA binding
Biological Process: DNA replication; DNA replication checkpoint; DNA replication initiation; double-strand break repair via break-induced replication; G1/S transition of mitotic cell cycle; G1/S-specific transcription in mitotic cell cycle; pre-replicative complex assembly; regulation of chromatin silencing at telomere