Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; EC 126.96.36.199; Protease; Motility/polarity/chemotaxis
Molecular Function: aspartic-type endopeptidase activity; protein binding
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagy; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; protein catabolic process; proteolysis
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.