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Protein Page:
CNTNAP2 (human)

Overview
CNTNAP2 May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: axolemma; cell surface; early endosome; Golgi apparatus; membrane; voltage-gated potassium channel complex
Molecular Function: enzyme binding
Biological Process: adult behavior; brain development; cerebral cortex development; clustering of voltage-gated potassium channels; learning; limbic system development; neurite development; social behavior; striatum development; thalamus development; vocal learning
Disease: Autism, Susceptibility To, 15; Cortical Dysplasia-focal Epilepsy Syndrome
Reference #:  Q9UHC6 (UniProtKB)
Alt. Names/Synonyms: AUTS15; CASPR2; CDFE; Cell recognition molecule Caspr2; CNTNAP2; CNTP2; contactin associated protein-like 2; contactin-associated protein 2; Contactin-associated protein-like 2; DKFZp781D1846; homolog of Drosophila neurexin IV; KIAA0868; NRXN4; PTHSL1
Gene Symbols: CNTNAP2
Molecular weight: 148,167 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CNTNAP2

Protein Structure Not Found.


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