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Protein Page:
MAML2 (human)

Overview
MAML2 Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa. Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. Belongs to the mastermind family. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: Golgi apparatus; nuclear speck; nucleoplasm; nucleus
Molecular Function: transcription coactivator activity
Biological Process: activation of Notch receptor target transcription factor; gene expression; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Reference #:  Q8IZL2 (UniProtKB)
Alt. Names/Synonyms: DKFZp686N0150; KIAA1819; Mam-2; MAM-3; MAM2; MAM3; MAML2; mastermind-like 2 (Drosophila); Mastermind-like protein 2; MGC176701; MLL-MAML2
Gene Symbols: MAML2
Molecular weight: 125,197 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MAML2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S78‑p ESTLQLLsLVQHGQG
0 2 S175‑p ALIALQGsLKRKQVV
0 1 S185‑p RKQVVNLsPANsKRP
0 2 S189‑p VNLsPANsKRPNGFV
0 1 S230‑p NGQSQIMsGtLPMsQ
0 1 T232‑p QSQIMsGtLPMsQAP
0 1 S236‑p MsGtLPMsQAPLRKT
0 1 Y513‑p QSKVMANyMyKAGPS
0 1 Y515‑p KVMANyMyKAGPSAQ
0 2 S1089‑p LTPSNFPsPNQSSRA
  mouse

 
S78 ESTMQLLSLVQHGQG
S170 ALLALQGSLKRKQIV
S180 RKQIVNLSPANSKRP
S184 VNLSPANSKRPNGFV
P225 NGQSQMMPGPLTMNQ
P227 QSQMMPGPLTMNQAP
N231 MPGPLTMNQAPLRKT
Y511 QSKAAANYTYKASPS
Y513 KAAANYTYKASPSAQ
S1103 LTPNAFPSSNQSSRA
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