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Protein Page:
MAML2 (human)

MAML2 Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa. Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. Belongs to the mastermind family. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q21
Cellular Component: Golgi apparatus; nucleoplasm; nucleus
Molecular Function: transcription coactivator activity
Biological Process: activation of Notch receptor target transcription factor; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
Reference #:  Q8IZL2 (UniProtKB)
Alt. Names/Synonyms: DKFZp686N0150; KIAA1819; Mam-2; MAM-3; MAM2; MAM3; MAML2; mastermind-like 2 (Drosophila); Mastermind-like protein 2; MGC176701; MLL-MAML2
Gene Symbols: MAML2
Molecular weight: 125,197 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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