Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: early endosome membrane; external side of plasma membrane; extracellular region; integral to plasma membrane; plasma membrane; T cell receptor complex
Molecular Function: coreceptor activity; MHC class I protein binding; protein binding
Biological Process: adaptive immune response; immune response; regulation of defense response to virus by virus; regulation of immune response; T cell activation; transmembrane receptor protein tyrosine kinase signaling pathway
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.