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Protein Page:
CD8B (human)
rdtyret
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD8B Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: early endosome membrane; external side of plasma membrane; extracellular region; integral to plasma membrane; plasma membrane; T cell receptor complex
Molecular Function: coreceptor activity; MHC class I protein binding; protein binding
Biological Process: adaptive immune response; immune response; regulation of defense response to virus by virus; regulation of immune response; T cell activation; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction
Reference #:  P10966 (UniProtKB)
Alt. Names/Synonyms: CD8 antigen, beta polypeptide (p37); CD8 antigen, beta polypeptide 1 (p37); CD8B; CD8b antigen; CD8b molecule; CD8B1; Leu2; Ly3; LYT3; MGC119115; T lymphocyte surface glycoprotein beta chain; T-cell surface glycoprotein CD8 beta chain
Gene Symbols: CD8B
Molecular weight: 23,722 Da
Basal Isoelectric point: 10.03  Predict pI for various phosphorylation states
Select Structure to View Below

CD8B

Protein Structure Not Found.


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Modification Sites and Domains  
Click here to view other types of protein modifications

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S40‑p TNKMVMLsCEAKISL
0 1 K77 LALWDSAKGTIHGEE
1 0 - gap
  CD8B iso3  
S40 TNKMVMLSCEAKISL
K77 LALWDSAKGTIHGEE
- gap
  CD8B iso4  
S40 TNKMVMLSCEAKISL
K77 LALWDSAKGTIHGEE
K215‑ub KFNIVCLkISGFTTC
  mouse

 
S40 TNHTAKMSCEVKSIS
K76‑ac LASWSSSkGVLYGES
- gap
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