Effector of integrin and growth factor signaling, coupling surface receptors to downstream signaling molecules involved in the regulation of cell survival, cell proliferation and cell differentiation. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: cytosol; focal adhesion; intercellular junction; perinuclear region of cytoplasm; plasma membrane
Molecular Function: protein binding; protein kinase binding; zinc ion binding
Biological Process: cell aging; epithelial to mesenchymal transition; establishment of protein localization; negative regulation of transcription, DNA-dependent; positive regulation of focal adhesion formation; positive regulation of GTPase activity; regulation of epithelial cell proliferation
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.